Isoxazole is an important pharmacophore that is critical for biological activity. The isoxazole
ring ranks 33rd in frequency among the 351 ring systems found in marketed drugs, thus …

Isoxazoles are an important class of heterocycles with nitrogen and oxygen in a 1, 2‐
relationship. They find wide applications in synthetic organic chemistry and are part of …

Abstract The 1, 3‐dipolar cycloaddition reactions (DCs) of nitrile oxides (NOs) to alkenes
and alkynes are useful methods for the synthesis of 2‐isoxazolines and isoxazoles …

Bromo‐3, 3, 3‐trifluoropropene (BTP) represents a highly valuable synthon in synthetic
chemistry, and has been widely used in organic synthesis, mainly including addition …

Intramolecular electrophilic aromatic substitution (SEAr) reaction at the 5-position of
isoxazoles was achieved. The electron-donating heteroatoms (N and O) at the 4-position of …

An efficient regioselective approach to novel functionalized bis (isoxazoles) with a variety of
aromatic and aliphatic linkers was elaborated, based on the heterocyclization reaction of …

An efficient oxidative [4+ 2] annulation of isoxazolyl-4-carboxylic acids with internal alkynes
proceeded in the presence of the [Cp* RhCl2] 2 catalyst. Oxidants controlled the formation of …

Sulfur-containing functional π-conjugated cores play key roles in materials science, mostly
due to their unique electrochemical and photophysical properties. Among these, the …

Nitro-substituted isoxazoles are of utmost interest both as versatile intermediates for targeted
organic synthesis and as perspective bioactive compounds for drug development …

The catalytic asymmetric electrophilic functionalization of the less reactive N-heteroaromatic
compounds has been reported using the approach of the introduction of an exocyclic amino …