Pyrazolines are five-membered heterocycles possessing two adjacent nitrogens. They have
attracted significant attention from organic and medicinal chemists due to their potent …

In recent years, synthetic lethality has been recognized as a solid paradigm for anticancer
therapies. The discovery of a growing number of synthetic lethal targets has led to a …

The superior dose distribution of particle radiation compared to photon radiation makes it a
promising therapy for the treatment of tumors. However, the cellular responses to particle …

The effective potency and resistance of poly (ADP-ribose) polymerase (PARP) inhibitors limit
their application. Here, we exploit a new paradigm that mimics the effects of breast cancer …

Personalized medicine and therapies represent the goal of modern medicine, as drug
discovery strives to move away from one-cure-for-all and makes use of the various targets …

Targeting DNA repair proteins with small-molecule inhibitors became a proven anti-cancer
strategy. Previously, we identified an inhibitor of a major protein of homologous …

Pancreatic ductal adenocarcinoma (PDAC) is the third leading cause of cancer-related
deaths in the United States. Although chemotherapeutic regimens such as gemcitabine+ …

Introduction Synthetic lethality (SL) provides an opportunity to leverage different genetic
interactions when designing synergistic combination therapies. To further explore SL-based …

Pancreatic cancer (PC) is characterized by (epi) genetic and microenvironmental alterations
that negatively impact the treatment outcomes. New targeted therapies have been pursued …

The vast majority of cancer patients receive DNA-damaging drugs or ionizing radiation (IR)
during their course of treatment, yet the efficacy of these therapies is tempered by DNA …