Clinical PET imaging of microglial activation: implications for microglial therapeutics in Alzheimer's disease

Z Shen, X Bao, R Wang - Frontiers in aging neuroscience, 2018 - frontiersin.org
In addition to extracellular β-amyloid plaques and intracellular neurofibrillary tangles,
neuroinflammation has been identified as a key pathological characteristic of Alzheimer's …

PET/MR imaging: new frontier in Alzheimer's disease and other dementias

XY Zhang, ZL Yang, GM Lu, GF Yang… - Frontiers in molecular …, 2017 - frontiersin.org
Alzheimer's disease (AD) is the most common form of dementia; a progressive
neurodegenerative disease that currently lacks an effective treatment option. Early and …

Ultra-high field imaging in Major Depressive Disorder: a review of structural and functional studies

G Cattarinussi, G Delvecchio, E Maggioni… - Journal of Affective …, 2021 - Elsevier
Background Major depressive disorder (MDD) is a severe and pervasive psychiatric
condition with a lifetime prevalence of 15–25%. Numerous Magnetic Resonance Imaging …

In vivo MRI signatures of hippocampal subfield pathology in intractable epilepsy

M Goubran, BC Bernhardt… - Human brain …, 2016 - Wiley Online Library
Objectives Our aim is to assess the subfield‐specific histopathological correlates of
hippocampal volume and intensity changes (T1, T2) as well as diff! usion MRI markers in …

In Vivo Imaging of Microglia With Multiphoton Microscopy

C Hierro-Bujalance, BJ Bacskai… - Frontiers in aging …, 2018 - frontiersin.org
Neuroimaging has become an unparalleled tool to understand the central nervous system
(CNS) anatomy, physiology and neurological diseases. While an altered immune function …

Investigation of hippocampal substructures in focal temporal lobe epilepsy with and without hippocampal sclerosis at 7T

BG Santyr, M Goubran, JC Lau… - Journal of Magnetic …, 2017 - Wiley Online Library
Purpose To provide a more detailed investigation of hippocampal subfields using 7T
magnetic resonance imaging (MRI) for the identification of hippocampal sclerosis in …

Fluorinated MRI contrast agents and their versatile applications in the biomedical field

E Hequet, C Henoumont, RN Muller… - Future medicinal …, 2019 - Taylor & Francis
MRI has been recognized as one of the most applied medical imaging techniques in clinical
practice. However, the presence of background signal coming from water protons in …

[HTML][HTML] Seven Tesla MRI in Alzheimer's disease research: State of the art and future directions: A narrative review

ASPM Arachchige, AK Garner - AIMS neuroscience, 2023 - ncbi.nlm.nih.gov
Seven tesla magnetic resonance imaging (7T MRI) is known to offer a superior spatial
resolution and a signal-to-noise ratio relative to any other non-invasive imaging technique …

Longitudinal changes in hippocampal subfield volume associated with collegiate football

SN Parivash, M Goubran, BD Mills, P Rezaii… - Journal of …, 2019 - liebertpub.com
Collegiate football athletes are subject to repeated traumatic brain injuriesthat may cause
brain injury. The hippocampus is composed of several distinct subfields with possible …

Assessment of pathological features in Alzheimer's disease brain tissue with a large field-of-view visible-light optical coherence microscope

A Lichtenegger, M Muck, P Eugui, DJ Harper… - …, 2018 - spiedigitallibrary.org
We implemented a wide field-of-view visible-light optical coherence microscope (OCM) for
investigating ex-vivo brain tissue of patients diagnosed with Alzheimer's disease (AD) and of …