Protein lysine methyltransferases (PKMTs) transfer up to three methyl groups to the side
chains of lysine residues in proteins and fulfill important regulatory functions by controlling …

Proteins interact with other proteins, with nucleic acids, lipids, carbohydrates and various
small molecules in the living cell. These interactions have been quantified and structurally …

Enzymes are known to sample various conformations, many of which are critical for their
biological function. However, structural characterizations of enzymes predominantly focus …

Tuberculosis is a contagious bacterial ailment that primarily affects the lungs and is brought
on by the bacterium Mycobacterium tuberculosis (MTB). An antimycobacterial medication …

Aromatic side chains are important reporters of the plasticity of proteins, and often form
important contacts in protein–protein interactions. We studied aromatic residues in the two …

Aromatic residues form a significant part of the protein core, where they make tight
interactions with multiple surrounding side chains. Despite the dense packing of internal …

Abstract Lactate dehydrogenase (LDH, EC. 1.1. 127) is an important enzyme engaged in the
anaerobic metabolism of cells, catalyzing the conversion of pyruvate to lactate and NADH to …

G protein-coupled receptor (GPCR) conformational plasticity enables formation of ternary
signaling complexes with intracellular proteins in response to binding extracellular ligands …

It is common for NMR relaxation dispersion experiments to suggest an absence of dynamics
despite anecdotal indications of conformational dynamics. We explore the potential …

The study of protein structure, dynamics and function by NMR spectroscopy commonly
requires samples that have been enriched ('labelled') with the stable isotopes 13C and/or …