The importance of immune gene variability (MHC) in evolutionary ecology and conservation

S Sommer - Frontiers in zoology, 2005 - Springer
Genetic studies have typically inferred the effects of human impact by documenting patterns
of genetic differentiation and levels of genetic diversity among potentially isolated …

[HTML][HTML] Advances in the evolutionary understanding of MHC polymorphism

J Radwan, W Babik, J Kaufman, TL Lenz, J Winternitz - Trends in Genetics, 2020 - cell.com
Proteins encoded by the classical major histocompatibility complex (MHC) genes incite the
vertebrate adaptive immune response by presenting peptide antigens on the cell surface …

The major histocompatibility complex, sexual selection, and mate choice

M Milinski - Annu. Rev. Ecol. Evol. Syst., 2006 - annualreviews.org
To maintain sexual reproduction, recombination of good genes through selective mate
choice must achieve a twofold genetic benefit in each generation.“Fragrant” immune genes …

Genetic and environmental determinants of human TCR repertoire diversity

C Krishna, D Chowell, M Gönen, Y Elhanati, TA Chan - Immunity & Ageing, 2020 - Springer
T cell discrimination of self and non-self is the foundation of the adaptive immune response,
and is orchestrated by the interaction between T cell receptors (TCRs) and their cognate …

Major histocompatibility complex diversity influences parasite resistance and innate immunity in sticklebacks

J Kurtz, M Kalbe, PB Aeschlimann… - … of the Royal …, 2004 - royalsocietypublishing.org
Proteins of the major histocompatibility complex (MHC) play a central role in the
presentation of antigens to the adaptive immune system. The MHC also influences the odour …

Effects of an MHC‐DRB genotype and allele number on the load of gut parasites in the bank vole Myodes glareolus

A Kloch, W Babik, A Bajer, E Siński… - Molecular …, 2010 - Wiley Online Library
The major histocompatibility complex (MHC) genes code for the proteins responsible for
pathogen recognition. The MHC class II DRB gene is multiplicated in the bank vole, Myodes …

Does intra-individual major histocompatibility complex diversity keep a golden mean?

B Woelfing, A Traulsen… - … Transactions of the …, 2009 - royalsocietypublishing.org
An adaptive immune response is usually initiated only if a major histocompatibility complex
(MHC) molecule presents pathogen-derived peptides to T-cells. Every MHC molecule can …

Lifetime reproductive success is maximized with optimal major histocompatibility complex diversity

M Kalbe, C Eizaguirre, I Dankert… - … of the Royal …, 2009 - royalsocietypublishing.org
Individual diversity at the major histocompatibility complex (MHC) is predicted to be optimal
at intermediate rather than at maximal levels. We showed previously in sticklebacks that an …

Major histocompatibility complex class I diversity limits the repertoire of T cell receptors

M Migalska, A Sebastian… - Proceedings of the …, 2019 - National Acad Sciences
Major histocompatibility complex (MHC) genes encode proteins that initiate adaptive
immune responses through the presentation of foreign antigens to T cells. The high …

Theories and quantification of thymic selection

AJ Yates - Frontiers in immunology, 2014 - frontiersin.org
The peripheral T cell repertoire is sculpted from prototypic T cells in the thymus bearing
randomly generated T cell receptors (TCR) and by a series of developmental and selection …