Structural biology of laminins
E Hohenester - Essays in biochemistry, 2019 - portlandpress.com
Laminins are large cell-adhesive glycoproteins that are required for the formation and
function of basement membranes in all animals. Structural studies by electron microscopy in …
function of basement membranes in all animals. Structural studies by electron microscopy in …
Laminin-inspired cell-instructive microenvironments for neural stem cells
D Barros, IF Amaral, AP Pego - Biomacromolecules, 2019 - ACS Publications
Laminin is a heterotrimeric glycoprotein with a key role in the formation and maintenance of
the basement membrane architecture and properties, as well as on the modulation of …
the basement membrane architecture and properties, as well as on the modulation of …
Multivalent coiled-coil interactions enable full-scale centrosome assembly and strength
MU Rios, MA Bagnucka, BD Ryder… - Journal of Cell …, 2024 - rupress.org
The outermost layer of centrosomes, called pericentriolar material (PCM), organizes
microtubules for mitotic spindle assembly. The molecular interactions that enable PCM to …
microtubules for mitotic spindle assembly. The molecular interactions that enable PCM to …
Coiled-coil domains are sufficient to drive liquid-liquid phase separation in protein models
Liquid-liquid phase separation (LLPS) is thought to be a main driving force in the formation
of membraneless organelles. Examples of such organelles include the centrosome, central …
of membraneless organelles. Examples of such organelles include the centrosome, central …
Missing regions within the molecular architecture of human fibrin clots structurally resolved by XL-MS and integrative structural modeling
O Klykov, C Van Der Zwaan… - Proceedings of the …, 2020 - National Acad Sciences
Upon activation, fibrinogen forms large fibrin biopolymers that coalesce into clots which
assist in wound healing. Limited insights into their molecular architecture, due to the sheer …
assist in wound healing. Limited insights into their molecular architecture, due to the sheer …
[HTML][HTML] Coiled-coil domains are sufficient to drive liquid-liquid phase separation of proteins in molecular models
Liquid-liquid phase separation (LLPS) is thought to be a main driving force in the formation
of membraneless organelles. Examples of such organelles include the centrosome, central …
of membraneless organelles. Examples of such organelles include the centrosome, central …
Robust formation of an epithelial layer of human intestinal organoids in a polydimethylsiloxane-based gut-on-a-chip microdevice
Polydimethylsiloxane (PDMS) is a silicone polymer that has been predominantly used in a
human organ-on-a-chip microphysiological system. The hydrophobic surface of a …
human organ-on-a-chip microphysiological system. The hydrophobic surface of a …
Neurothreads: development of supportive carriers for mature dopaminergic neuron differentiation and implantation
A Filippova, F Bonini, L Efremova, M Locatelli… - Biomaterials, 2021 - Elsevier
In this study we present the use of elastic macroporous cryogels for differentiation and
transplantation of mature neurons. We develop a coating suitable for long-term neuronal …
transplantation of mature neurons. We develop a coating suitable for long-term neuronal …
Crystal structure of the heterotrimeric integrin-binding region of laminin-111
D Pulido, SA Hussain, E Hohenester - Structure, 2017 - cell.com
Laminins are cell-adhesive glycoproteins that are essential for basement membrane
assembly and function. Integrins are important laminin receptors, but their binding site on the …
assembly and function. Integrins are important laminin receptors, but their binding site on the …
Mechanotransduction through adhesion molecules: Emerging roles in regulating the stem cell niche
R Lim, A Banerjee, R Biswas, AN Chari… - Frontiers in Cell and …, 2022 - frontiersin.org
Stem cells have been shown to play an important role in regenerative medicine due to their
proliferative and differentiation potential. The challenge, however, lies in regulating and …
proliferative and differentiation potential. The challenge, however, lies in regulating and …