Insulin resistance (IR) plays a crucial role in the development and progression of
metabolism-related diseases such as diabetes, hypertension, tumors, and nonalcoholic fatty …

The prevalence of obesity and associated chronic diseases continues to increase
worldwide, negatively impacting on societies and economies. Whereas the association …

The tumor microenvironment (TME) is comprised of non-malignant cells that interact with
each other and with cancer cells, critically impacting cancer biology. The TME is complex …

Exercise has been recommended as an important strategy to improve glucose metabolism
in obesity. Adipose tissue fibrosis is associated with inflammation and is implicated in …

Fibrosis in adipose tissue is a major driver of obesity-related metabolic dysregulation. It is
characterized by an overaccumulation of extracellular matrix (ECM) during unhealthy …

Obesity is associated with chronic low-grade inflammation. The benefits of exercise are
partly attributed to its anti-inflammatory effect, but whether exercise can regulate NLRP3 …

Obesity, a major global health concern, is characterized by serious imbalance between
energy intake and expenditure leading to excess accumulation of fat in adipose tissue (AT) …

Obesity is an ever-increasing phenomenon, with 42% of Americans being considered obese
(BMI≥ 30) and 9.2% being considered morbidly obese (BMI≥ 40) as of 2016. With obesity …

The expansion of adipose tissue is an adaptive mechanism that increases nutrient buffering
capacity in response to an overall positive energy balance. Over the course of expansion …

Adipose tissue is a widely distributed organ that plays a critical role in age-related
physiological dysfunctions as an important source of chronic sterile low-grade inflammation …