The crucial role and mechanism of insulin resistance in metabolic disease
X Zhao, X An, C Yang, W Sun, H Ji… - Frontiers in endocrinology, 2023 - frontiersin.org
Insulin resistance (IR) plays a crucial role in the development and progression of
metabolism-related diseases such as diabetes, hypertension, tumors, and nonalcoholic fatty …
metabolism-related diseases such as diabetes, hypertension, tumors, and nonalcoholic fatty …
White adipocyte dysfunction and obesity-associated pathologies in humans
CE Hagberg, KL Spalding - Nature Reviews Molecular Cell Biology, 2024 - nature.com
The prevalence of obesity and associated chronic diseases continues to increase
worldwide, negatively impacting on societies and economies. Whereas the association …
worldwide, negatively impacting on societies and economies. Whereas the association …
The tumor microenvironment shows a hierarchy of cell-cell interactions dominated by fibroblasts
The tumor microenvironment (TME) is comprised of non-malignant cells that interact with
each other and with cancer cells, critically impacting cancer biology. The TME is complex …
each other and with cancer cells, critically impacting cancer biology. The TME is complex …
Exercise retards ongoing adipose tissue fibrosis in diet-induced obese mice
L Li, Y Wei, C Fang, S Liu, F Zhou, G Zhao… - Endocrine …, 2021 - ec.bioscientifica.com
Exercise has been recommended as an important strategy to improve glucose metabolism
in obesity. Adipose tissue fibrosis is associated with inflammation and is implicated in …
in obesity. Adipose tissue fibrosis is associated with inflammation and is implicated in …
[HTML][HTML] Extracellular matrix (ECM) and fibrosis in adipose tissue: overview and perspectives
Fibrosis in adipose tissue is a major driver of obesity-related metabolic dysregulation. It is
characterized by an overaccumulation of extracellular matrix (ECM) during unhealthy …
characterized by an overaccumulation of extracellular matrix (ECM) during unhealthy …
[HTML][HTML] Exercise inhibits NLRP3 inflammasome activation in obese mice via the anti-inflammatory effect of meteorin-like
HMA Javaid, NE Sahar, DL ZhuGe, JY Huh - Cells, 2021 - mdpi.com
Obesity is associated with chronic low-grade inflammation. The benefits of exercise are
partly attributed to its anti-inflammatory effect, but whether exercise can regulate NLRP3 …
partly attributed to its anti-inflammatory effect, but whether exercise can regulate NLRP3 …
Adipose tissue macrophages and their role in obesity-associated insulin resistance: an overview of the complex dynamics at play
S Guria, A Hoory, S Das, D Chattopadhyay… - Bioscience …, 2023 - portlandpress.com
Obesity, a major global health concern, is characterized by serious imbalance between
energy intake and expenditure leading to excess accumulation of fat in adipose tissue (AT) …
energy intake and expenditure leading to excess accumulation of fat in adipose tissue (AT) …
Adipose tissue paracrine-, autocrine-, and matrix-dependent signaling during the development and progression of obesity
EK Johnston, RD Abbott - Cells, 2023 - mdpi.com
Obesity is an ever-increasing phenomenon, with 42% of Americans being considered obese
(BMI≥ 30) and 9.2% being considered morbidly obese (BMI≥ 40) as of 2016. With obesity …
(BMI≥ 30) and 9.2% being considered morbidly obese (BMI≥ 40) as of 2016. With obesity …
Importance of the microenvironment and mechanosensing in adipose tissue biology
S Lecoutre, M Lambert, K Drygalski, I Dugail… - Cells, 2022 - mdpi.com
The expansion of adipose tissue is an adaptive mechanism that increases nutrient buffering
capacity in response to an overall positive energy balance. Over the course of expansion …
capacity in response to an overall positive energy balance. Over the course of expansion …
Adipose tissue aging is regulated by an altered immune system
YX Zhang, MY Ou, ZH Yang, Y Sun, QF Li… - Frontiers in …, 2023 - frontiersin.org
Adipose tissue is a widely distributed organ that plays a critical role in age-related
physiological dysfunctions as an important source of chronic sterile low-grade inflammation …
physiological dysfunctions as an important source of chronic sterile low-grade inflammation …