More than a decade after a Nobel Prize was awarded for the discovery of the ubiquitin–
proteasome system and clinical approval of proteasome and ubiquitin E3 ligase inhibitors …

Cancer is a global issue majorly affecting developing countries. According to a survey, 63%
of deaths due to cancer are reported from developing countries. There are different …

Abstract Anti-PD-1/PD-L1 immunotherapy has achieved impressive therapeutic outcomes in
patients with multiple cancer types. However, the underlined molecular mechanism (s) for …

Cushing's disease is caused by corticotroph adenomas of the pituitary. To explore the
molecular mechanisms of endocrine autonomy in these tumors, we performed exome …

Endocytosis is the major regulator of signaling from receptor tyrosine kinases (RTKs). The
canonical model of RTK endocytosis involves rapid internalization of an RTK activated by …

Ubiquitylation is a major posttranslational modification that controls most complex aspects of
cell physiology. It is reversed through the action of a large family of deubiquitylating …

Cushing's disease, also known as adrenocorticotropic hormone (ACTH)-secreting pituitary
adenomas (PAs) that cause excess cortisol production, accounts for up to 85% of …

Cell signalling and endocytic membrane trafficking have traditionally been viewed as distinct
processes. Although our present understanding is incomplete and there are still great …

Human-made information relay systems invariably incorporate central regulatory
components, which are mirrored in biological systems by dense feedback and feedforward …

Newly synthesized transmembrane proteins undergo a series of steps to ensure that only
the required amount of correctly folded protein is localized to the membrane. The regulation …