It has been 15 years since the birth of human induced pluripotent stem cell (iPSC)
technology in 2007, and the scope of its application has been expanding. In addition to the …

Amyotrophic lateral sclerosis (ALS) is an intractable disease that causes respiratory failure
leading to mortality. The main locus of ALS is motor neurons. The success of antisense …

Understanding the pathogenic mechanisms of disease mutations is critical to advancing
treatments. ALS-associated mutations in the gene encoding the microtubule motor KIF5A …

Neuromuscular junctions (NMJs) ensure communication between motor neurons (MNs) and
muscle; however, in MN disorders, such as amyotrophic lateral sclerosis (ALS), NMJs …

The intrinsic cellular heterogeneity and molecular complexity of the mammalian nervous
system relies substantially on the dynamic nature and spatiotemporal patterning of gene …

Mutations in the RNA-binding protein (RBP) FUS have been genetically associated with the
motoneuron disease amyotrophic lateral sclerosis (ALS). Using both human induced …

Therapeutic advances for neurological disorders are challenging due to limited accessibility
of the human central nervous system and incomplete understanding of disease …

Many neurodegenerative diseases (NDs) such as Alzheimer's disease, Parkinson's disease,
frontotemporal dementia, amyotrophic lateral sclerosis and Huntington's disease, are …

Amyotrophic lateral sclerosis (ALS) is a fatal disease characterized by aberrant alternative
splicing (AS). Nuclear loss and cytoplasmic accumulation of the splicing factor TDP-43 in …

Amyotrophic lateral sclerosis (ALS) is an intractable adult-onset neurodegenerative disease
that leads to the loss of upper and lower motor neurons (MNs). The long axons of MNs …