In higher plants, invertases hydrolyze sucrose (Suc), the major end product of
photosynthesis, into glucose (Glc) and fructose (Fru), which are used as nutrients, energy …

Understanding complex systems often requires a bottom-up analysis towards a systems
biology approach. The need to investigate a system, not only as individual components but …

The differentiation of IL-10-producing regulatory B cells (Bregs) in response to gut-
microbiota-derived signals supports the maintenance of tolerance. However, whether …

Heatmapper is a freely available web server that allows users to interactively visualize their
data in the form of heat maps through an easy-to-use graphical interface. Unlike existing non …

Aging is associated with an increased risk of cardiovascular disease and death. Here we
show that oral supplementation of the natural polyamine spermidine extends the lifespan of …

Bone regeneration relies on the activation of skeletal stem cells (SSCs) that still remain
poorly characterized. Here, we show that periosteum contains SSCs with high bone …

Brain tumors are among the most lethal and devastating cancers. Their study is limited by
genetic heterogeneity and the incompleteness of available laboratory models. Three …

Immune cells constitute an important element of tumor tissue. Accumulating evidence
indicates their clinicopathological significance in predicting prognosis and therapeutic …

Metformin is the most commonly prescribed medication for type 2 diabetes, owing to its
glucose-lowering effects, which are mediated through the suppression of hepatic glucose …

Mitochondria are central participants in a variety of cellular processes including ATP
generation, programmed cell death, signal transduction, and innate immunity …