Intracellular pathogens: host immunity and microbial persistence strategies

A Thakur, H Mikkelsen… - Journal of immunology …, 2019 - Wiley Online Library
Infectious diseases caused by pathogens including viruses, bacteria, fungi, and parasites
are ranked as the second leading cause of death worldwide by the World Health …

Function and regulation of IL‐1α in inflammatory diseases and cancer

A Malik, TD Kanneganti - Immunological reviews, 2018 - Wiley Online Library
Summary The interleukin (IL)‐1 family of cytokines is currently comprised of 11 members
that have pleiotropic functions in inflammation and cancer. IL‐1α and IL‐1β were the first …

[HTML][HTML] Clash of the Cytokine Titans: counter-regulation of interleukin-1 and type I interferon-mediated inflammatory responses

KD Mayer-Barber, B Yan - Cellular & molecular immunology, 2017 - nature.com
Over the past decades the notion of 'inflammation'has been extended beyond the original
hallmarks of rubor (redness), calor (heat), tumor (swelling) and dolor (pain) described by …

Chlamydial intracellular survival strategies

RJ Bastidas, CA Elwell… - Cold Spring …, 2013 - perspectivesinmedicine.cshlp.org
Chlamydia trachomatis is the most common sexually transmitted bacterial pathogen and the
causative agent of blinding trachoma. Although Chlamydia is protected from humoral …

Human and pathogen factors associated with Chlamydia trachomatis-related infertility in women

S Menon, P Timms, JA Allan, K Alexander… - Clinical microbiology …, 2015 - Am Soc Microbiol
Chlamydia trachomatis is the most common bacterial sexually transmitted pathogen
worldwide. Infection can result in serious reproductive pathologies, including pelvic …

Chlamydial plasmid-dependent pathogenicity

G Zhong - Trends in microbiology, 2017 - cell.com
Most Chlamydia species carry a 7.5 kb plasmid encoding eight open reading frames
conventionally called plasmid glycoproteins 1–8 or pGP1–8. Although the plasmid is not …

A genome-wide profiling of the humoral immune response to Chlamydia trachomatis infection reveals vaccine candidate antigens expressed in humans

J Wang, Y Zhang, C Lu, L Lei, P Yu… - The Journal of …, 2010 - journals.aai.org
A whole genome scale proteome array consisting of 908 open reading frames encoded in
Chlamydia trachomatis genome and plasmid was used to profile anti-chlamydial Ab …

Characterization of Chlamydia trachomatis plasmid-encoded open reading frames

S Gong, Z Yang, L Lei, L Shen, G Zhong - Journal of bacteriology, 2013 - Am Soc Microbiol
The recent success in transformation of Chlamydia trachomatis represents a major
advancement in Chlamydia research. Plasmid-free C. trachomatis serovar L2 organisms can …

[HTML][HTML] Interleukin 1 alpha administration is neuroprotective and neuro-restorative following experimental ischemic stroke

KE Salmeron, ME Maniskas, DN Edwards… - Journal of …, 2019 - Springer
Background Stroke remains a leading cause of death and disability worldwide despite
recent treatment breakthroughs. A primary event in stroke pathogenesis is the development …

Development status and future prospects for a vaccine against Chlamydia trachomatis infection

LM Hafner, DP Wilson, P Timms - Vaccine, 2014 - Elsevier
Chlamydia trachomatis continues to be the most commonly reported sexually transmitted
bacterial infection in many countries with more than 100 million new cases estimated …