Context During the past 2 decades, a major transition in the clinical characterization of
psychotic disorders has occurred. The construct of a clinical high-risk (HR) state for …

Despite a lack of recent progress in the treatment of schizophrenia, our understanding of its
genetic and environmental causes has considerably improved, and their relationship to …

Context A substantial proportion of people at clinical high risk of psychosis will develop a
psychotic disorder over time. However, the risk of transition to psychosis varies between …

The aim of this guidance paper of the European Psychiatric Association is to provide
evidence-based recommendations on the early detection of a clinical high risk (CHR) for …

This guidance paper from the European Psychiatric Association (EPA) aims to provide
evidence-based recommendations on early intervention in clinical high risk (CHR) states of …

Importance A promising treatment to prevent onset and improve outcomes in patients at
ultrahigh risk for psychosis is dietary supplementation with long-chain ω-3 polyunsaturated …

Objective To determine whether any psychological, pharmacological, or nutritional
interventions can prevent or delay transition to psychotic disorders for people at high risk …

Over the last decade many studies were conducted to assess the feasibility of early
detection of people at risk of developing psychosis and intervention to prevent or delay a first …

Importance The ultra high-risk (UHR) criteria were introduced to prospectively identify
patients at high risk of psychotic disorder. Although the short-term outcome of UHR patients …

Scientific progress in understanding human disease can be measured by the effectiveness
of its treatment. Antipsychotic drugs have been proven to alleviate acute psychotic symptoms …