From actin waves to mechanism and back: how theory aids biological understanding

C Beta, L Edelstein-Keshet, N Gov, A Yochelis - Elife, 2023 - elifesciences.org
Actin dynamics in cell motility, division, and phagocytosis is regulated by complex factors
with multiple feedback loops, often leading to emergent dynamic patterns in the form of …

A minimal cell model for lamellipodia-based cellular dynamics and migration

RK Sadhu, A Iglič, NS Gov - Journal of Cell Science, 2023 - journals.biologists.com
One ubiquitous cellular structure for performing various tasks, such as spreading and
migration over external surfaces, is the sheet-like protrusion called a lamellipodium, which …

Spatiotemporal dynamics of membrane surface charge regulates cell polarity and migration

T Banerjee, D Biswas, DS Pal, Y Miao, PA Iglesias… - Nature cell …, 2022 - nature.com
During cell migration and polarization, numerous signal transduction and cytoskeletal
components self-organize to generate localized protrusions. Although biochemical and …

Ras suppression potentiates rear actomyosin contractility-driven cell polarization and migration

Y Lin, DS Pal, P Banerjee, T Banerjee, G Qin… - Nature cell …, 2024 - nature.com
Ras has been extensively studied as a promoter of cell proliferation, whereas few studies
have explored its role in migration. To investigate the direct and immediate effects of Ras …

An excitable Ras/PI3K/ERK signaling network controls migration and oncogenic transformation in epithelial cells

H Zhan, S Bhattacharya, H Cai, PA Iglesias… - Developmental Cell, 2020 - cell.com
Summary The Ras/PI3K/extracellular signal-regulated kinases (ERK) signaling network
plays fundamental roles in cell growth, survival, and migration and is frequently activated in …

The phonon theory of liquids and biological fluids: Developments and applications

D Bolmatov - The Journal of Physical Chemistry Letters, 2022 - ACS Publications
Among the three basic states of matter (solid, liquid, and gas), the liquid state has always
eluded general theoretical approaches for describing liquid energy and heat capacity. In this …

Time-reversal and parity-time symmetry breaking in non-Hermitian field theories

T Suchanek, K Kroy, SAM Loos - Physical Review E, 2023 - APS
We study time-reversal symmetry breaking in non-Hermitian fluctuating field theories with
conserved dynamics, comprising the mesoscopic descriptions of a wide range of …

A dynamic partitioning mechanism polarizes membrane protein distribution

T Banerjee, S Matsuoka, D Biswas, Y Miao… - Nature …, 2023 - nature.com
The plasma membrane is widely regarded as the hub of the numerous signal transduction
activities. Yet, the fundamental biophysical mechanisms that spatiotemporally …

Irreversible mesoscale fluctuations herald the emergence of dynamical phases

T Suchanek, K Kroy, SAM Loos - Physical Review Letters, 2023 - APS
We study fluctuating field models with spontaneously emerging dynamical phases. We
consider two typical transition scenarios associated with parity-time symmetry breaking …

Progress on Physical Field‐Regulated Micro/Nanomotors for Cardiovascular and Cerebrovascular Disease Treatment

Q You, X Shao, J Wang, X Chen - Small Methods, 2023 - Wiley Online Library
Cardiovascular and cerebrovascular diseases (CCVDs) are two major vasculature‐related
diseases that seriously affect public health worldwide, which can cause serious death and …