The peptide hormone leptin regulates food intake, body mass, and reproductive function and
plays a role in fetal growth, proinflammatory immune responses, angiogenesis and lipolysis …

Obesity, a major risk factor for the development of diabetes mellitus, cardiovascular diseases
and certain types of cancer, arises from a chronic positive energy balance that is often due to …

After its discovery as a key controller of metabolic function, leptin has been later extensively
implicated in additional functions including important modulatory activities on the innate and …

Obesity is a chronic illness associated with several metabolic derangements and
comorbidities (ie, insulin resistance, leptin resistance, diabetes, etc.) and often leads to …

The cloning of leptin in 1994 was an important milestone in obesity research. In those days
obesity was stigmatized as a condition caused by lack of character and self-control …

Leptin is now considered an important signalling molecule of the reproductive system, as it
regulates the production of gonadotrophins, the blastocyst formation and implantation, the …

The adipose tissue–derived hormone leptin acts via its receptor (LRb) in the brain to
regulate energy balance and neuroendocrine function. LRb signaling via STAT3 and a …

The discovery of the archetypal adipocytokine leptin and how it regulates energy
homeostasis have represented breakthroughs in our understanding of the endocrine …

Leptin has not evolved as a therapeutic modality for the treatment of obesity due to the
prevalence of leptin resistance in a majority of the obese population. Nevertheless, the …

In November 1955, Geoffrey Harris published a paper based on the Christian A Herter
Lecture he had given earlier that year at Johns Hopkins University in Baltimore, MD, USA …