Regulatory mechanism of MicroRNA expression in cancer
Z Ali Syeda, SSS Langden, C Munkhzul, M Lee… - International journal of …, 2020 - mdpi.com
Altered gene expression is the primary molecular mechanism responsible for the
pathological processes of human diseases, including cancer. MicroRNAs (miRNAs) are …
pathological processes of human diseases, including cancer. MicroRNAs (miRNAs) are …
Alternative mechanisms of miR-34a regulation in cancer
MicroRNA miR-34a is recognized as a master regulator of tumor suppression. The strategy
of miR-34a replacement has been investigated in clinical trials as the first attempt of miRNA …
of miR-34a replacement has been investigated in clinical trials as the first attempt of miRNA …
Genetics and epigenetics of rheumatoid arthritis
Investigators have made key advances in rheumatoid arthritis (RA) genetics in the past 10
years. Although genetic studies have had limited influence on clinical practice and drug …
years. Although genetic studies have had limited influence on clinical practice and drug …
MicroRNA-34a: a potential therapeutic target in human cancer
XJ Li, ZJ Ren, JH Tang - Cell death & disease, 2014 - nature.com
MicroRNAs (miRs) are small noncoding RNAs that negatively regulate gene expression by
binding to the three untranslated regions of their target mRNAs. Deregulations of miRs were …
binding to the three untranslated regions of their target mRNAs. Deregulations of miRs were …
MicroRNAs in B-cell lymphomas: how a complex biology gets more complex
K Musilová, M Mráz - Leukemia, 2015 - nature.com
MicroRNAs (miRNAs) represent important regulators of gene expression besides
transcriptional control. miRNA regulation can be involved in the cell developmental fate …
transcriptional control. miRNA regulation can be involved in the cell developmental fate …
Intragenic DNA methylation in transcriptional regulation, normal differentiation and cancer
M Kulis, AC Queirós, R Beekman… - Biochimica et Biophysica …, 2013 - Elsevier
Ever since the discovery of DNA methylation at cytosine residues, the role of this so called
fifth base has been extensively studied and debated. Until recently, the majority of DNA …
fifth base has been extensively studied and debated. Until recently, the majority of DNA …
Childhood abuse is associated with methylation of multiple loci in adult DNA
M Suderman, N Borghol, JJ Pappas… - BMC medical …, 2014 - Springer
Background Childhood abuse is associated with increased adult disease risk, suggesting
that processes acting over the long-term, such as epigenetic regulation of gene activity, may …
that processes acting over the long-term, such as epigenetic regulation of gene activity, may …
Mutual regulation of microRNAs and DNA methylation in human cancers
S Wang, W Wu, FX Claret - Epigenetics, 2017 - Taylor & Francis
ABSTRACT microRNAs (miRNAs) and DNA methylation are the 2 epigenetic modifications
that have emerged in recent years as the most critical players in the regulation of gene …
that have emerged in recent years as the most critical players in the regulation of gene …
Genomic and epigenomic heterogeneity in chronic lymphocytic leukemia
R Guièze, CJ Wu - Blood, The Journal of the American Society …, 2015 - ashpublications.org
Defining features of chronic lymphocytic leukemia (CLL) are not only its immunophenotype
of CD19+ CD5+ CD23+ sIgdim expressing clonal mature B cells but also its highly variable …
of CD19+ CD5+ CD23+ sIgdim expressing clonal mature B cells but also its highly variable …