Right heart dysfunction and failure in heart failure with preserved ejection fraction: mechanisms and management. Position statement on behalf of the Heart Failure …

TM Gorter, DJ van Veldhuisen… - European journal of …, 2018 - Wiley Online Library
There is an unmet need for effective treatment strategies to reduce morbidity and mortality in
patients with heart failure with preserved ejection fraction (HFpEF). Until recently, attention in …

Current and future treatments of pulmonary arterial hypertension

N Sommer, HA Ghofrani, O Pak… - British journal of …, 2021 - Wiley Online Library
Therapeutic options for pulmonary arterial hypertension (PAH) have increased over the last
decades. The advent of pharmacological therapies targeting the prostacyclin, endothelin …

Tsantan Sumtang attenuated chronic hypoxia-induced right ventricular structure remodeling and fibrosis by equilibrating local ACE-AngII-AT1R/ACE2-Ang1-7-Mas …

Z Dang, S Su, G Jin, X Nan, L Ma, Z Li, D Lu… - Journal of …, 2020 - Elsevier
Abstract Ethnopharmacological relevance Tsantan Sumtang, which consists of
Choerospondias axillaris (Roxb.) Burtt et Hill, Myristica fragrans Houtt and Santalum album …

Fibroblasts and the extracellular matrix in right ventricular disease

NG Frangogiannis - Cardiovascular research, 2017 - academic.oup.com
Right ventricular failure predicts adverse outcome in patients with pulmonary hypertension
(PH), and in subjects with left ventricular heart failure and is associated with interstitial …

Right heart in pulmonary hypertension: from adaptation to failure

X Ren, RA Johns, WD Gao - Pulmonary circulation, 2019 - journals.sagepub.com
Right ventricular (RV) failure (RVF) has garnered significant attention in recent years
because of its negative impact on clinical outcomes in patients with pulmonary hypertension …

Review on chamber-specific differences in right and left heart reactive oxygen species handling

KD Schlüter, HS Kutsche, C Hirschhäuser… - Frontiers in …, 2018 - frontiersin.org
Reactive oxygen species (ROS) exert signaling character (redox signaling), or damaging
character (oxidative stress) on cardiac tissue depending on their concentration and/or …

New drugs, therapeutic strategies, and future direction for the treatment of pulmonary arterial hypertension

V Mercurio, A Bianco, G Campi… - Current medicinal …, 2019 - ingentaconnect.com
Despite recent advances in Pulmonary Arterial Hypertension (PAH) treatment, this condition
is still characterized by an extremely poor prognosis. In this review, we discuss the use of …

Pulmonary arterial hypertension: the case for a bioelectronic treatment

D Ntiloudi, K Qanud, JN Tomaio, G Giannakoulas… - Bioelectronic …, 2019 - Springer
Pulmonary arterial hypertension (PAH) is a rare disease of unknown etiology that
progresses to right ventricular failure. It has a complex pathophysiology, which involves an …

Device-based sympathetic nerve regulation for cardiovascular diseases

L Li, Z Hu, Y Xiong, Y Yao - Frontiers in Cardiovascular Medicine, 2021 - frontiersin.org
Sympathetic overactivation plays an important role in promoting a variety of
pathophysiological processes in cardiovascular diseases (CVDs), including ventricular …

Physiology of the right ventricle across the lifespan

KC Woulfe, LA Walker - Frontiers in Physiology, 2021 - frontiersin.org
The most common cause of heart failure in the United States is ischemic left heart disease;
accordingly, a vast amount of work has been done to elucidate the molecular mechanisms …