Abstract Background Antiepileptic drugs (AEDs) are effective medications available for
epilepsy. However, many patients do not respond to this treatment and become resistant …

Several studies examined a possible link between multidrug resistance-associated protein 2
(ABCC2) gene variants and the risk of resistance to antiepileptic drugs (AEDs) in epilepsy …

The GABA receptor is an important epilepsy-associated candidate gene, and has always
been a focus in etiology and in the treatment of epilepsy. This study explores the genetic …

Background Pediatric epilepsy is a complicated neuropsychiatric disorder that is
characterized by recurrent seizures and unusual synchronized electrical activities within …

Genetic polymorphisms are related to the concentration and efficacy of oxcarbazepine
(OXC). 10-Hydroxycarbazepine (MHD) is the major pharmacologically active metabolite of …

Mesial temporal lobe epilepsy (MTLE) is a common epileptic disorder; little is known
whether it is associated with peripheral epigenetic changes. Here we compared blood …

Purpose There is a large inter-individual variation in the efficacy of valproic acid (VPA)
against epilepsy. The genetic polymorphism influence of sodium channels on VPA response …

Background Epilepsy is one of the most common neurological diseases with unclear
etiology where its genetic background and treatment regime still need further exploration …

Epilepsy is a common disease of the nervous system; approximately 20-30% of all patients
with epilepsy are reported resistant to antiepileptic drugs. ABCB1 and ABCC2 are members …

Sodium channel blocking antiepileptic drugs (SCB-AEDs) are common effective medications
available for epilepsy. However, not all patients respond to this regimen and drug resistance …