Targeting SARS-CoV-2 receptors as a means for reducing infectivity and improving antiviral and immune response: an algorithm-based method for overcoming …

R Gelman, A Bayatra, A Kessler… - Emerging microbes & …, 2020 - Taylor & Francis
The ongoing severe acute respiratory syndrome pandemic caused by the novel coronavirus
2 (SARS-CoV-2) is associated with high morbidity and mortality rates, and it has created a …

Progress and trends in mathematical modelling of influenza A virus infections

A Handel, LE Liao, CAA Beauchemin - Current Opinion in Systems Biology, 2018 - Elsevier
Mathematical modelling of influenza A virus infection has seen increased use over the last
several years. Models applied to both in vitro and in vivo data have provided important new …

SARS‐CoV‐2 coinfections: Could influenza and the common cold be beneficial?

L Pinky, HM Dobrovolny - Journal of Medical Virology, 2020 - Wiley Online Library
The novel coronavirus severe acute respiratory syndrome coronavirus 2 (SARS‐CoV‐2) has
rapidly spread around the world, causing serious illness and death and creating a heavy …

Evolutionary safety of lethal mutagenesis driven by antiviral treatment

G Lobinska, Y Pilpel, MA Nowak - PLoS biology, 2023 - journals.plos.org
Nucleoside analogs are a major class of antiviral drugs. Some act by increasing the viral
mutation rate causing lethal mutagenesis of the virus. Their mutagenic capacity, however …

A mathematical model describing the localization and spread of influenza A virus infection within the human respiratory tract

C Quirouette, NP Younis, MB Reddy… - PLoS computational …, 2020 - journals.plos.org
Within the human respiratory tract (HRT), virus diffuses through the periciliary fluid (PCF)
bathing the epithelium. But virus also undergoes advection: as the mucus layer sitting atop …

Antiviral drug screen of kinase inhibitors identifies cellular signaling pathways critical for SARS-CoV-2 replication

G Garcia Jr, A Sharma, A Ramaiah, C Sen, D Kohn… - BioRxiv, 2020 - biorxiv.org
Emergence of a highly contagious novel coronavirus, SARS-CoV-2 that causes COVID-19,
has precipitated the current global health crisis with over 479,000 deaths and more than 9.3 …

Antiviral peptides as anti-influenza agents

M Agamennone, M Fantacuzzi, G Vivenzio… - International Journal of …, 2022 - mdpi.com
Influenza viruses represent a leading cause of high morbidity and mortality worldwide.
Approaches for fighting flu are seasonal vaccines and some antiviral drugs. The …

Initial inoculum and the severity of COVID-19: A mathematical modeling study of the dose-response of SARS-CoV-2 infections

B Fain, HM Dobrovolny - Epidemiologia, 2020 - mdpi.com
SARS-CoV-2 (Severe acute respiratory syndrome coronavirus 2) causes a variety of
responses in those who contract the virus, ranging from asymptomatic infections to acute …

Anti-influenza strategies based on nanoparticle applications

K Wieczorek, B Szutkowska, E Kierzek - Pathogens, 2020 - mdpi.com
Influenza virus has the potential for being one of the deadliest viruses, as we know from the
pandemic's history. The influenza virus, with a constantly mutating genome, is becoming …

The evolution of Tamiflu synthesis, 20 years on: Advent of enabling technologies the last piece of the puzzle?

CR Sagandira, FM Mathe, U Guyo, P Watts - Tetrahedron, 2020 - Elsevier
Influenza is a serious respiratory disease responsible for significant morbidity and mortality
due to both annual epidemics and pandemics; its treatment involves the use of …