Liver cirrhosis is the final pathological result of various chronic liver diseases, and fibrosis is
the precursor of cirrhosis. Many types of cells, cytokines and miRNAs are involved in the …

Hepatic stellate cells are resident perisinusoidal cells distributed throughout the liver, with a
remarkable range of functions in normal and injured liver. Derived embryologically from …

Small, noncoding microRNAs (miRNAs) regulate diverse biological functions in the liver and
increasing evidence suggests that they have a role in liver pathology. This Review …

MicroRNAs (miRNA) are small non-coding RNAs (∼ 22 nt in length) that are known as
potent master regulators of eukaryotic gene expression. miRNAs have been shown to play a …

Fibrotic diseases encompass a wide spectrum of clinical entities including systemic fibrotic
diseases such as systemic sclerosis, sclerodermatous graft versus host disease …

Recently non-alcoholic fatty liver disease (NAFLD) has grabbed considerable scientific
attention, owing to its rapid increase in prevalence worldwide and growing burden on end …

Background & Aims Hepatic stellate cells (HSCs) play a key role in liver fibrosis in various
chronic liver disorders including nonalcoholic fatty liver disease (NAFLD). The development …

Pancreatic ductal adenocarcinoma (PDAC) is one of the most lethal human malignancies
with a 5-year survival rate of 8%. Dense, fibrotic stroma associated with pancreatic tumors is …

Human fibrotic diseases constitute a major health problem worldwide owing to the large
number of affected individuals, the incomplete knowledge of the fibrotic process …

Homeobox transcript antisense RNA (HOTAIR), as a long intergenic non-coding RNA
(lincRNA), is upregulated in various cancers and involved in diverse cellular functions …