[HTML][HTML] Rhodopsin, light-sensor of vision
KP Hofmann, TD Lamb - Progress in Retinal and Eye Research, 2023 - Elsevier
The light sensor of vertebrate scotopic (low-light) vision, rhodopsin, is a G-protein-coupled
receptor comprising a polypeptide chain with bound chromophore, 11-cis-retinal, that …
receptor comprising a polypeptide chain with bound chromophore, 11-cis-retinal, that …
Membranes under the magnetic lens: a dive into the diverse world of membrane protein structures using Cryo-EM
Membrane proteins are highly diverse in both structure and function and can, therefore,
present different challenges for structure determination. They are biologically important for …
present different challenges for structure determination. They are biologically important for …
[HTML][HTML] Structural basis of tethered agonism of the adhesion GPCRs ADGRD1 and ADGRF1
X Qu, N Qiu, M Wang, B Zhang, J Du, Z Zhong, W Xu… - Nature, 2022 - nature.com
Adhesion G protein-coupled receptors (aGPCRs) are essential for a variety of physiological
processes such as immune responses, organ development, cellular communication …
processes such as immune responses, organ development, cellular communication …
[HTML][HTML] Structural insights into multiplexed pharmacological actions of tirzepatide and peptide 20 at the GIP, GLP-1 or glucagon receptors
Glucose homeostasis, regulated by glucose-dependent insulinotropic polypeptide (GIP),
glucagon-like peptide-1 (GLP-1) and glucagon (GCG) is critical to human health. Several …
glucagon-like peptide-1 (GLP-1) and glucagon (GCG) is critical to human health. Several …
Structural determinants of dual incretin receptor agonism by tirzepatide
B Sun, FS Willard, D Feng… - Proceedings of the …, 2022 - National Acad Sciences
Tirzepatide (LY3298176) is a fatty-acid-modified, dual incretin receptor agonist that exhibits
pharmacology similar to native GIP at the glucose-dependent insulinotropic polypeptide …
pharmacology similar to native GIP at the glucose-dependent insulinotropic polypeptide …
Structures of Gi-bound metabotropic glutamate receptors mGlu2 and mGlu4
S Lin, S Han, X Cai, Q Tan, K Zhou, D Wang, X Wang… - Nature, 2021 - nature.com
The metabotropic glutamate receptors (mGlus) have key roles in modulating cell excitability
and synaptic transmission in response to glutamate (the main excitatory neurotransmitter in …
and synaptic transmission in response to glutamate (the main excitatory neurotransmitter in …
[HTML][HTML] Differential GLP-1R binding and activation by peptide and non-peptide agonists
Peptide drugs targeting class B1 G-protein-coupled receptors (GPCRs) can treat multiple
diseases; however, there remains substantial interest in the development of orally delivered …
diseases; however, there remains substantial interest in the development of orally delivered …
[HTML][HTML] Tail engagement of arrestin at the glucagon receptor
K Chen, C Zhang, S Lin, X Yan, H Cai, C Yi, L Ma… - Nature, 2023 - nature.com
Arrestins have pivotal roles in regulating G protein-coupled receptor (GPCR) signalling by
desensitizing G protein activation and mediating receptor internalization,. It has been …
desensitizing G protein activation and mediating receptor internalization,. It has been …
[HTML][HTML] Ligand recognition and G-protein coupling selectivity of cholecystokinin A receptor
Cholecystokinin A receptor (CCKAR) belongs to family A G-protein-coupled receptors and
regulates nutrient homeostasis upon stimulation by cholecystokinin (CCK). It is an attractive …
regulates nutrient homeostasis upon stimulation by cholecystokinin (CCK). It is an attractive …
[HTML][HTML] Specific binding of GPR174 by endogenous lysophosphatidylserine leads to high constitutive Gs signaling
Y Nie, Z Qiu, S Chen, Z Chen, X Song, Y Ma… - Nature …, 2023 - nature.com
Many orphan G protein-coupled receptors (GPCRs) remain understudied because their
endogenous ligands are unknown. Here, we show that a group of class A/rhodopsin-like …
endogenous ligands are unknown. Here, we show that a group of class A/rhodopsin-like …