Bioluminescence (BL) is a spectacular phenomenon involving light emission by live
organisms. It is caused by the oxidation of a small organic molecule, luciferin, with molecular …

ABSTRACT The 3Rs–Replacement, Reduction and Refinement–are embedded into the
legislation and guidelines governing the ethics of animal use in experiments. Here, we …

Superparamagnetic iron oxide nanoparticles (SPION) have emerged as an MRI contrast
agent for tumor imaging due to their efficacy and safety. Their utility has been proven in …

This review describes general concepts with regard to radiopharmaceuticals for diagnostic
or therapeutic applications that help to understand the specific challenges encountered …

Recent advances in the development of new methods of cancer immunotherapy require the
production of complex cancer animal models that reliably reflect the complexity of the tumor …

Most cancer patients receive chemotherapy at some stage of their treatment which makes
improving the efficacy of cytotoxic drugs an ongoing and important goal. Despite large …

Image guided drug delivery using imageable thermosensitive liposomes (iTSLs) and high
intensity focused ultrasound (FUS or HIFU) has attracted interest as a novel and non …

Increasing accumulation and retention of nanomedicines within tumor tissue is a significant
challenge, particularly in the case of brain tumors where access to the tumor through the …

Nanocomposite polymeric gels infused with fluorescent nanoparticles have surfaced as a
propitious category of substances for biomedical purposes owing to their exceptional …

Regenerative medicine therapies hold enormous potential for a variety of currently incurable
conditions with high unmet clinical need. Most progress in this field to date has been …