Halfway between 2D and animal models: are 3D cultures the ideal tool to study cancer-microenvironment interactions?
An area that has come to be of tremendous interest in tumor research in the last decade is
the role of the microenvironment in the biology of neoplastic diseases. The tumor …
the role of the microenvironment in the biology of neoplastic diseases. The tumor …
Three-Dimensional Cell Culture: A Breakthrough in Vivo
D Antoni, H Burckel, E Josset, G Noel - International journal of molecular …, 2015 - mdpi.com
Cell culture is an important tool for biological research. Two-dimensional cell culture has
been used for some time now, but growing cells in flat layers on plastic surfaces does not …
been used for some time now, but growing cells in flat layers on plastic surfaces does not …
Engineering multi‐cellular spheroids for tissue engineering and regenerative medicine
Multi‐cellular spheroids are formed as a 3D structure with dense cell–cell/cell–extracellular
matrix interactions, and thus, have been widely utilized as implantable therapeutics and …
matrix interactions, and thus, have been widely utilized as implantable therapeutics and …
Opportunities and challenges for use of tumor spheroids as models to test drug delivery and efficacy
Multicellular spheroids are three dimensional in vitro microscale tissue analogs. The current
article examines the suitability of spheroids as an in vitro platform for testing drug delivery …
article examines the suitability of spheroids as an in vitro platform for testing drug delivery …
Spheroids-on-a-chip: Recent advances and design considerations in microfluidic platforms for spheroid formation and culture
A cell spheroid is a three-dimensional (3D) aggregation of cells. Synthetic, in-vitro spheroids
provide similar metabolism, proliferation, and species concentration gradients to those found …
provide similar metabolism, proliferation, and species concentration gradients to those found …
[HTML][HTML] Engineering cancer microenvironments for in vitro 3-D tumor models
The natural microenvironment of tumors is composed of extracellular matrix (ECM), blood
vasculature, and supporting stromal cells. The physical characteristics of ECM as well as the …
vasculature, and supporting stromal cells. The physical characteristics of ECM as well as the …
Design of spherically structured 3D in vitro tumor models-Advances and prospects
Three-dimensional multicellular tumor models are receiving an ever-growing focus as
preclinical drug-screening platforms due to their potential to recapitulate major physiological …
preclinical drug-screening platforms due to their potential to recapitulate major physiological …
Reconfigurable microfluidic hanging drop network for multi-tissue interaction and analysis
Integration of multiple three-dimensional microtissues into microfluidic networks enables
new insights in how different organs or tissues of an organism interact. Here, we present a …
new insights in how different organs or tissues of an organism interact. Here, we present a …
Emerging tumor spheroids technologies for 3D in vitro cancer modeling
T Rodrigues, B Kundu, J Silva-Correia… - Pharmacology & …, 2018 - Elsevier
Cancer is a leading cause of mortality and morbidity worldwide. Around 90% of deaths are
caused by metastasis and just 10% by primary tumor. The advancement of treatment …
caused by metastasis and just 10% by primary tumor. The advancement of treatment …
High-content monitoring of drug effects in a 3D spheroid model
A recent decline in the discovery of novel medications challenges the widespread use of 2D
monolayer cell assays in the drug discovery process. As a result, the need for more …
monolayer cell assays in the drug discovery process. As a result, the need for more …