Modulation of immune responses by particle size and shape

MV Baranov, M Kumar, S Sacanna… - Frontiers in …, 2021 - frontiersin.org
The immune system has to cope with a wide range of irregularly shaped pathogens that can
actively move (eg, by flagella) and also dynamically remodel their shape (eg, transition from …

The effects of neutrophil-generated hypochlorous acid and other hypohalous acids on host and pathogens

A Ulfig, LI Leichert - Cellular and Molecular Life Sciences, 2021 - Springer
Neutrophils are predominant immune cells that protect the human body against infections by
deploying sophisticated antimicrobial strategies including phagocytosis of bacteria and …

The cytoskeleton in phagocytosis and macropinocytosis

S Mylvaganam, SA Freeman, S Grinstein - Current Biology, 2021 - cell.com
Cells of the innate immune system, notably macrophages, neutrophils and dendritic cells,
perform essential antimicrobial and homeostatic functions. These functions rely on the …

Phagocytic 'teeth'and myosin-II 'jaw'power target constriction during phagocytosis

D Vorselen, SR Barger, Y Wang, W Cai, JA Theriot… - Elife, 2021 - elifesciences.org
Phagocytosis requires rapid actin reorganization and spatially controlled force generation to
ingest targets ranging from pathogens to apoptotic cells. How actomyosin activity directs …

The formation and function of the neutrophil phagosome

E Naish, AJT Wood, AP Stewart… - Immunological …, 2023 - Wiley Online Library
Neutrophils are the most abundant circulating leukocyte and are crucial to the initial innate
immune response to infection. One of their key pathogen‐eliminating mechanisms is …

A theoretical model of efficient phagocytosis driven by curved membrane proteins and active cytoskeleton forces

RK Sadhu, SR Barger, S Penič, A Iglič, M Krendel… - Soft Matter, 2023 - pubs.rsc.org
Phagocytosis is the process of engulfment and internalization of comparatively large
particles by cells, and plays a central role in the functioning of our immune system. We study …

Nanoparticle spikes enhance cellular uptake via regulating myosin IIA recruitment

L Huang, X Mao, J Li, Q Li, J Shen, M Liu, C Fan… - ACS …, 2023 - ACS Publications
Spike-like nanostructures are omnipresent in natural and artificial systems. Although
biorecognition of nanostructures to cellular receptors has been indicated as the primary …

Microparticles: biogenesis, characteristics and intervention therapy for cancers in preclinical and clinical research

Y Hu, Y Sun, C Wan, X Dai, S Wu, PC Lo… - Journal of …, 2022 - Springer
Extracellular vesicles (EVs), spherical biological vesicles, mainly contain nucleic acids,
proteins, lipids and metabolites for biological information transfer between cells …

[HTML][HTML] A mechanical perspective on phagocytic cup formation

D Vorselen, RLD Labitigan, JA Theriot - Current opinion in cell biology, 2020 - Elsevier
Phagocytosis is a widespread and evolutionarily conserved process with diverse biological
functions, ranging from engulfment of invading microbes during infection to clearance of …

Deficiency of macrophage PHACTR1 impairs efferocytosis and promotes atherosclerotic plaque necrosis

C Kasikara, M Schilperoort, B Gerlach… - The Journal of …, 2021 - Am Soc Clin Investig
Efferocytosis, the process through which apoptotic cells (ACs) are cleared through actin-
mediated engulfment by macrophages, prevents secondary necrosis, suppresses …