Modulation of immune responses by particle size and shape
The immune system has to cope with a wide range of irregularly shaped pathogens that can
actively move (eg, by flagella) and also dynamically remodel their shape (eg, transition from …
actively move (eg, by flagella) and also dynamically remodel their shape (eg, transition from …
The effects of neutrophil-generated hypochlorous acid and other hypohalous acids on host and pathogens
A Ulfig, LI Leichert - Cellular and Molecular Life Sciences, 2021 - Springer
Neutrophils are predominant immune cells that protect the human body against infections by
deploying sophisticated antimicrobial strategies including phagocytosis of bacteria and …
deploying sophisticated antimicrobial strategies including phagocytosis of bacteria and …
The cytoskeleton in phagocytosis and macropinocytosis
Cells of the innate immune system, notably macrophages, neutrophils and dendritic cells,
perform essential antimicrobial and homeostatic functions. These functions rely on the …
perform essential antimicrobial and homeostatic functions. These functions rely on the …
Phagocytic 'teeth'and myosin-II 'jaw'power target constriction during phagocytosis
Phagocytosis requires rapid actin reorganization and spatially controlled force generation to
ingest targets ranging from pathogens to apoptotic cells. How actomyosin activity directs …
ingest targets ranging from pathogens to apoptotic cells. How actomyosin activity directs …
The formation and function of the neutrophil phagosome
E Naish, AJT Wood, AP Stewart… - Immunological …, 2023 - Wiley Online Library
Neutrophils are the most abundant circulating leukocyte and are crucial to the initial innate
immune response to infection. One of their key pathogen‐eliminating mechanisms is …
immune response to infection. One of their key pathogen‐eliminating mechanisms is …
A theoretical model of efficient phagocytosis driven by curved membrane proteins and active cytoskeleton forces
Phagocytosis is the process of engulfment and internalization of comparatively large
particles by cells, and plays a central role in the functioning of our immune system. We study …
particles by cells, and plays a central role in the functioning of our immune system. We study …
Nanoparticle spikes enhance cellular uptake via regulating myosin IIA recruitment
Spike-like nanostructures are omnipresent in natural and artificial systems. Although
biorecognition of nanostructures to cellular receptors has been indicated as the primary …
biorecognition of nanostructures to cellular receptors has been indicated as the primary …
Microparticles: biogenesis, characteristics and intervention therapy for cancers in preclinical and clinical research
Y Hu, Y Sun, C Wan, X Dai, S Wu, PC Lo… - Journal of …, 2022 - Springer
Extracellular vesicles (EVs), spherical biological vesicles, mainly contain nucleic acids,
proteins, lipids and metabolites for biological information transfer between cells …
proteins, lipids and metabolites for biological information transfer between cells …
[HTML][HTML] A mechanical perspective on phagocytic cup formation
D Vorselen, RLD Labitigan, JA Theriot - Current opinion in cell biology, 2020 - Elsevier
Phagocytosis is a widespread and evolutionarily conserved process with diverse biological
functions, ranging from engulfment of invading microbes during infection to clearance of …
functions, ranging from engulfment of invading microbes during infection to clearance of …
Deficiency of macrophage PHACTR1 impairs efferocytosis and promotes atherosclerotic plaque necrosis
C Kasikara, M Schilperoort, B Gerlach… - The Journal of …, 2021 - Am Soc Clin Investig
Efferocytosis, the process through which apoptotic cells (ACs) are cleared through actin-
mediated engulfment by macrophages, prevents secondary necrosis, suppresses …
mediated engulfment by macrophages, prevents secondary necrosis, suppresses …