Metallothioneins (MTs) are small cysteine-rich proteins that play important roles in metal
homeostasis and protection against heavy metal toxicity, DNA damage, and oxidative stress …

Humans are exposed to a significant number of chemicals that are suspected to produce
disturbances in hormone homeostasis. Hence, in recent decades, there has been a growing …

Apart from alterations in the RET/PTC-RAS-BRAF pathway, comparatively little is known
about the genetics of papillary thyroid carcinoma (PTC). We show that numerous microRNAs …

Currently, there is no completely effective therapy available for metastatic
phaeochromocytomas (PCCs) and paragangliomas. In this study, we explore new molecular …

Purpose An estimated 4% to 7% of the population will develop a clinically significant thyroid
nodule during their lifetime. In many cases, preoperative diagnoses by needle biopsy are …

The antiapoptotic, antioxidant, proliferative, and angiogenic effects of metallothionein (MT)-
I+ II has resulted in increased focus on their role in oncogenesis, tumor progression, therapy …

DNA methylation is an important component of epigenetic modifications, which influences
the transcriptional machinery aberrant in many human diseases. In this study we present the …

This study was designed to evaluate the changes in promoter CpG islands hypermethylation
during breast cancer progression from pre-invasive lesions [flat epithelial atypia (FEA) …

Background: Gene silencing through CpG island hypermethylation is a major mechanism in
cancer development. In the present study, we aimed to identify and validate novel target …

LATS1 and LATS2 are tumor suppressor genes implicated in the regulation of cell cycle, but
their methylation statuses are still unknown in human astrocytoma. Here, we found that the …