This review aims to survey the current state of mechanotransduction in vascular smooth
muscle cells (VSMCs) and endothelial cells (ECs), including their sensing of mechanical …

Haemodynamic forces influence the functional properties of vascular endothelium.
Endothelial cells (ECs) have a variety of receptors, which sense flow and transmit …

Atherosclerosis develops preferentially at branches and curvatures of the arterial tree, where
blood flow pattern is disturbed rather than being laminar, and wall shear stress has an …

Vascular endothelial cells (ECs) are exposed to hemodynamic forces, which modulate EC
functions and vascular biology/pathobiology in health and disease. The flow patterns and …

Different blood flow patterns in the arteries can alter the adaptive phenotype of vascular
endothelial cells (ECs), thereby affecting the functions of ECs and are directly associated …

Prostacyclin (PGI2) is a member of the prostanoid group of eicosanoids that regulate
homeostasis, hemostasis, smooth muscle function and inflammation. Prostanoids are …

Rationale: Endothelial microRNA-126 (miR-126) modulates vascular development and
angiogenesis. However, its role in the regulation of smooth muscle cell (SMC) function is …

Understanding how vascular wall endothelial cells (ECs), smooth muscle cells (SMCs), and
fibroblasts (FBs) sense and transduce the stimuli of hemodynamic forces (shear stress …

The peroxisome proliferator-activated receptors, PPARα, PPARβ, and PPARγ, are a family of
transcription factors activated by a diversity of molecules including fatty acids and fatty acid …

Arterial dissections, which involve an abrupt tear in the wall of a major artery resulting in the
intramural accumulation of blood, are a family of catastrophic disorders causing major …