The epidemiology, pathogenesis, transmission, diagnosis, and management of multidrug-resistant, extensively drug-resistant, and incurable tuberculosis

K Dheda, T Gumbo, G Maartens, KE Dooley… - The lancet Respiratory …, 2017 - thelancet.com
Global tuberculosis incidence has declined marginally over the past decade, and
tuberculosis remains out of control in several parts of the world including Africa and Asia …

Scaling up interventions to achieve global tuberculosis control: progress and new developments

M Raviglione, B Marais, K Floyd, K Lönnroth… - The Lancet, 2012 - thelancet.com
Tuberculosis is still one of the most important causes of death worldwide. The 2010 Lancet
tuberculosis series provided a comprehensive overview of global control efforts and …

[HTML][HTML] Emergence and spread of extensively and totally drug-resistant tuberculosis, South Africa

M Klopper, RM Warren, C Hayes… - Emerging infectious …, 2013 - ncbi.nlm.nih.gov
Factors driving the increase in drug-resistant tuberculosis (TB) in the Eastern Cape
Province, South Africa, are not understood. A convenience sample of 309 drug-susceptible …

Long-term outcomes of patients with extensively drug-resistant tuberculosis in South Africa: a cohort study

E Pietersen, E Ignatius, EM Streicher, B Mastrapa… - The Lancet, 2014 - thelancet.com
Background Long-term treatment-related outcomes in patients with extensively drug-
resistant (XDR) tuberculosis are unknown. We followed up a cohort of patients to address …

Methodological and clinical aspects of the molecular epidemiology of Mycobacterium tuberculosis and other mycobacteria

T Jagielski, A Minias, J van Ingen… - Clinical microbiology …, 2016 - Am Soc Microbiol
Molecular typing has revolutionized epidemiological studies of infectious diseases,
including those of a mycobacterial etiology. With the advent of fingerprinting techniques …

[HTML][HTML] Silver Nanoparticles Synthesized by Using the Endophytic Bacterium Pantoea ananatis are Promising Antimicrobial Agents against Multidrug Resistant …

T Monowar, MS Rahman, SJ Bhore, G Raju… - Molecules, 2018 - mdpi.com
Antibiotic resistance is one of the most important global problems currently confronting the
world. Different biomedical applications of silver nanoparticles (AgNPs) have indicated them …

[HTML][HTML] Mycobacterium tuberculosis Transmission in High-Incidence Settings—New Paradigms and Insights

M Coleman, L Martinez, G Theron, R Wood, B Marais - Pathogens, 2022 - mdpi.com
Tuberculosis has affected humankind for thousands of years, but a deeper understanding of
its cause and transmission only arose after Robert Koch discovered Mycobacterium …

Point‐of‐care diagnosis of tuberculosis: Past, present and future

K Dheda, M Ruhwald, G Theron, J Peter… - Respirology, 2013 - Wiley Online Library
Diagnosis represents only one aspect of tuberculosis (TB) control but is perhaps one of the
most challenging. The drawbacks of current tools highlight several unmet needs in TB …

The diagnostic accuracy of the GenoType® MTBDRsl assay for the detection of resistance to second‐line anti‐tuberculosis drugs

G Theron, J Peter, M Richardson… - Cochrane Database …, 2014 - cochranelibrary.com
Background Accurate and rapid tests for tuberculosis (TB) drug resistance are critical for
improving patient care and decreasing the transmission of drug‐resistant TB. Genotype® …

Revisiting susceptibility testing in MDR-TB by a standardized quantitative phenotypic assessment in a European multicentre study

E Cambau, M Viveiros, D Machado… - Journal of …, 2015 - academic.oup.com
Objectives Treatment outcome of MDR-TB is critically dependent on the proper use of
second-line drugs as per the result of in vitro drug susceptibility testing (DST). We aimed to …