Giardia duodenalis: biology and pathogenesis

RD Adam - Clinical microbiology reviews, 2021 - Am Soc Microbiol
Giardia duodenalis captured the attention of Leeuwenhoek in 1681 while he was examining
his own diarrheal stool, but, ironically, it did not really gain attention as a human pathogen …

Giardia spp. and the Gut Microbiota: Dangerous Liaisons

E Fekete, T Allain, A Siddiq, O Sosnowski… - Frontiers in …, 2021 - frontiersin.org
Alteration of the intestinal microbiome by enteropathogens is commonly associated with
gastrointestinal diseases and disorders and has far-reaching consequences for overall …

Drug resistance in Giardia: Mechanisms and alternative treatments for Giardiasis

R Argüello-García, D Leitsch, T Skinner-Adams… - Advances in …, 2020 - Elsevier
The use of chemotherapeutic drugs is the main resource against clinical giardiasis due to
the lack of approved vaccines. Resistance of G. duodenalis to the most used drugs to treat …

Pathogenesis and post-infectious complications in giardiasis

T Allain, AG Buret - Advances in parasitology, 2020 - Elsevier
Giardia is an important cause of diarrhoea, and results in post-infectious and extra-intestinal
complications. This chapter presents a state-of-the art of our understanding of how this …

Anti-Giardia Drug Discovery: Current Status and Gut Feelings

A Riches, CJS Hart, KR Trenholme… - Journal of medicinal …, 2020 - ACS Publications
Giardia parasites are ubiquitous protozoans of global importance that impact a wide range
of animals including humans. They are the most common enteric pathogen of cats and dogs …

Extracellular Cysteine Proteases of Key Intestinal Protozoan Pathogens—Factors Linked to Virulence and Pathogenicity

R Argüello-García, JC Carrero… - International Journal of …, 2023 - mdpi.com
Intestinal diseases caused by protistan parasites of the genera Giardia (giardiasis),
Entamoeba (amoebiasis), Cryptosporidium (cryptosporidiosis) and Blastocystis …

Giardia duodenalis and Its Secreted PPIB Trigger Inflammasome Activation and Pyroptosis in Macrophages through TLR4-Induced ROS Signaling and A20-Mediated …

L Liu, Y Yang, R Fang, W Zhu, J Wu, X Li, JV Patankar… - Cells, 2021 - mdpi.com
The extracellular protozoan parasite Giardia duodenalis is a well-known and important
causative agent of diarrhea on a global scale. Macrophage pyroptosis has been recognized …

Giardia duodenalis virulence—“to be, or not to be”

R Argüello-García, MG Ortega-Pierres - Current Tropical Medicine Reports, 2021 - Springer
Purpose of review Here, we review recent progress made on the genetic characterization of
Giardia duodenalis assemblages and their relationship with virulence. We also discuss the …

Mucosal Defense Against Giardia at the Intestinal Epithelial Cell Interface

S Solaymani-Mohammadi - Frontiers in immunology, 2022 - frontiersin.org
Human giardiasis, caused by the protozoan parasite Giardia duodenalis (syn. Giardia
lamblia, Giardia intestinalis, Lamblia intestinalis), is one of the most commonly-identified …

Recent insights into innate and adaptive immune responses to Giardia

SM Singer, MY Fink, VV Angelova - Advances in parasitology, 2019 - Elsevier
Infection with Giardia produces a wide range of clinical outcomes. Acutely infected patients
may have no overt symptoms or suffer from severe cramps, diarrhea, nausea and even …