Abstract Sirtuin 3 (SIRT3), an NAD+-dependent deacetylase, plays a key role in the
modulation of metabolic reprogramming and regulation of cell death, as well as in shaping …

TRAP1, the mitochondrial component of the Hsp90 family of molecular chaperones, displays
important bioenergetic and proteostatic functions. In tumor cells, TRAP1 contributes to shape …

Exercise in later life is important for bone health and delays the progression of osteoporotic
bone loss. Osteocytes are the major bone cells responsible for transforming mechanical …

Neurofibromatosis type 1, a genetic disorder caused by pathogenic germline variations in
NF1, predisposes individuals to the development of tumors, including cutaneous and …

Mitochondrial dysfunction and cell death play important roles in diabetic cardiomyopathy,
but the underlying mechanisms remain unclear. Here, we report that mitochondrial …

An NAD+-dependent deacetylase called Sirtuin 3 (Sirt3) is involved in the metabolic
processes of the mitochondria, including energy generation, the tricarboxylic acid cycle, and …

The neurofibromatosis-1 gene (NF1) was initially characterized because its germline
mutation is responsible for an inherited syndromic disease predisposing tumor …

Mitochondrial homeostasis is of great importance for cartilage integrity and associated with
the progression of osteoarthritis (OA); however, the underlying mechanisms are unknown …

Nitric oxide (NO) is a gaseous signaling molecule able to modify protein structure and
activity (Rizza and Filomeni, 2017). The addition of the NO moiety to a cysteine thiol is called …

The mitochondrial chaperone TRAP1 exerts a protective function in cells exposed to diverse
stress conditions in both physiological and pathological contexts. In cancer cells, it …