The unique structural and functional features of CXCL12

R Janssens, S Struyf, P Proost - Cellular & molecular immunology, 2018 - nature.com
The CXC chemokine CXCL12 is an important factor in physiological and pathological
processes, including embryogenesis, hematopoiesis, angiogenesis and inflammation …

[HTML][HTML] Regulation of CXCR4 signaling

JM Busillo, JL Benovic - Biochimica et Biophysica Acta (BBA) …, 2007 - Elsevier
The chemokine receptor CXCR4 belongs to the large superfamily of G protein-coupled
receptors, and is directly involved in a number of biological processes including …

Diversity and inter-connections in the CXCR4 chemokine receptor/ligand family: molecular perspectives

L Pawig, C Klasen, C Weber, J Bernhagen… - Frontiers in …, 2015 - frontiersin.org
CXCR4 and its ligand CXCL12 mediate the homing of progenitor cells in the bone marrow
and their recruitment to sites of injury, as well as affect processes such as cell arrest …

Cytokine and chemokine regulation of sensory neuron function

RJ Miller, H Jung, SK Bhangoo, FA White - Sensory nerves, 2009 - Springer
Pain normally subserves a vital role in the survival of the organism, prompting the avoidance
of situations associated with tissue damage. However, the sensation of pain can become …

Pharmacological modulation of chemokine receptor function

DJ Scholten, M Canals, D Maussang… - British journal of …, 2012 - Wiley Online Library
G protein‐coupled chemokine receptors and their peptidergic ligands are interesting
therapeutic targets due to their involvement in various immune‐related diseases, including …

Chemokines and the pathophysiology of neuropathic pain

FA White, H Jung, RJ Miller - Proceedings of the National …, 2007 - National Acad Sciences
Chemokines and chemokine receptors are widely expressed by cells of the immune and
nervous systems. This review focuses on our current knowledge concerning the role of …

CXCL12 chemokine and its receptors as major players in the interactions between immune and nervous systems

A Guyon - Frontiers in cellular neuroscience, 2014 - frontiersin.org
The chemokine CXCL12/stromal cell-derived factor 1 alpha has first been described in the
immune system where it functions include chemotaxis for lymphocytes and macrophages …

Chemokines: integrators of pain and inflammation

FA White, SK Bhangoo, RJ Miller - Nature reviews Drug discovery, 2005 - nature.com
Chronic (neuropathic) pain is one of the most widespread and intractable of human
complaints, as well as being one of the most difficult syndromes to treat successfully with …

Bioluminescence resonance energy transfer reveals ligand-induced conformational changes in CXCR4 homo-and heterodimers

Y Percherancier, YA Berchiche, I Slight… - Journal of Biological …, 2005 - ASBMB
Homo-and heterodimerization have emerged as prominent features of G-protein-coupled
receptors with possible impact on the regulation of their activity. Using a sensitive …

STIM1–Orai1 interactions and Orai1 conformational changes revealed by live‐cell FRET microscopy

L Navarro‐Borelly, A Somasundaram… - The Journal of …, 2008 - Wiley Online Library
Ca2+ entry through store‐operated Ca2+ release‐activated Ca2+ (CRAC) channels initiates
key functions such as gene expression and exocytosis of inflammatory mediators. Activation …