Heterocycles have long been the focus of intensive study in attempts to develop novel
therapeutic compounds, and acridine, a polynuclear nitrogen molecule containing a …

Since the start of the 21st century, antibiotic drug discovery and development from natural
products has experienced a certain renaissance. Currently, basic scientific research in …

The discovery of new effective DNA-targeted antitumor agent is needed because of their
clinical significance. As acridines can intercalate into DNA and benzimidazoles have the …

Blood pressure levels are directly associated with cardiovascular and cerebrovascular
morbidity and mortality, rendering arterial hypertension a major public health problem …

Mitochondria impart a crucial role in the regulation of programmed cell death and reactive
oxygen species (ROS) generation, besides serving as a primary energy source …

The leaves of Camellia sinensis (L.) are the source of tea, the second most consumed
beverage worldwide. Tea contains several chemical compounds such as polyphenols …

Design, Synthesis, and Anticancer Activity of Novel Enmein-Type Diterpenoid Derivatives
Targeting the PI3K/Akt/mTOR Signaling Pathway Jiafeng Wang, Conceptualization …

Background The development of platinum-based metal complexes in oncology is limited
due to vigorous toxicity and drug resistance. Objectives This work aimed to study the …

Understanding the relationship between agricultural intensification and ancient
sociopolitical complexity is a question that has long resonated with archaeological research …

Background: The lack of efficacious therapy for advanced melanoma and neuroblastoma
makes new approaches necessary. Therefore, many scientists seek new, more effective …