The roles and activation of endocardial Notch signaling in heart regeneration
H Li, C Chang, X Li, R Zhang - Cell Regeneration, 2021 - Springer
As a highly conserved signaling pathway in metazoans, the Notch pathway plays important
roles in embryonic development and tissue regeneration. Recently, cardiac injury and …
roles in embryonic development and tissue regeneration. Recently, cardiac injury and …
Emerging Signaling Regulation of Sinoatrial Node Dysfunction
Abstract Purpose of Review The sinoatrial node (SAN), the natural pacemaker of the heart,
is responsible for generating electrical impulses and initiating each heartbeat. Sinoatrial …
is responsible for generating electrical impulses and initiating each heartbeat. Sinoatrial …
Single cell evaluation of endocardial Hand2 gene regulatory networks reveals HAND2-dependent pathways that impact cardiac morphogenesis
The transcription factor HAND2 plays essential roles during cardiogenesis. Hand2
endocardial deletion (H2CKO) results in tricuspid atresia or double inlet left ventricle with …
endocardial deletion (H2CKO) results in tricuspid atresia or double inlet left ventricle with …
Basic fibroblast growth factor inhibits aortic valvular interstitial cells calcification via Notch1 pathway
Y Gao, N Li, Q Xue, X Fan, X Liu… - Journal of Investigative …, 2022 - journals.sagepub.com
Calcific aortic valve disease (CAVD) is an active pathological process mediated by
abnormal activation and transdifferentiation of valvular interstitial cells (VICs). The present …
abnormal activation and transdifferentiation of valvular interstitial cells (VICs). The present …
The molecular and cellular mechanisms of heart pacemaker development in vertebrates
VS Kuzmin, AA Kamensky - Moscow University Biological Sciences …, 2021 - Springer
A small group of specialized myocardial cells constitutes a natural dominant heart
pacemaker in the so-called sinoatrial node (SAN). The SAN determines proper heart …
pacemaker in the so-called sinoatrial node (SAN). The SAN determines proper heart …
Trends in research on sick sinus syndrome: A bibliometric analysis from 2000 to 2022
X Zhang, Y Zhao, Y Zhou, J Lv, J Peng… - Frontiers in …, 2022 - frontiersin.org
Sick sinus syndrome (SSS) is a refractory arrhythmia disease caused by the pathological
changes of sinoatrial node and its adjacent tissues. 2,251 publications related to SSS were …
changes of sinoatrial node and its adjacent tissues. 2,251 publications related to SSS were …
Novel insights into the sinoatrial node in single-cell RNA sequencing: from developmental biology to physiological function
W Fan, C Yang, X Hou, J Wan, B Liao - Journal of Cardiovascular …, 2022 - mdpi.com
Normal cardiac automaticity is dependent on the pacemaker cells of the sinoatrial node
(SAN). Insufficient cardiac pacemaking leads to the development of sick sinus syndrome …
(SAN). Insufficient cardiac pacemaking leads to the development of sick sinus syndrome …
Notch 信号通路与先天性心脏病
田坤灵， 陈川宁 - 协和医学杂志, 2024 - xhyxzz.pumch.cn
先天性心脏病(congenital heart disease, CHD) 指胎儿在胚胎时期的心脏发育异常,
通常伴有大血管发育不良, 其发病机制复杂, 目前尚未阐明. 研究表明, Notch …
通常伴有大血管发育不良, 其发病机制复杂, 目前尚未阐明. 研究表明, Notch …
Advances and Prospects in Understanding Vertebrate Cardiac Conduction System, Pacemaker Cell, and Cardiac Muscle Development: Toward Novel Biological …
The heart is composed of muscle cells called cardiomyocytes, including a specialized
population named pacemaker cells that form the cardiac conduction system (CCS), which is …
population named pacemaker cells that form the cardiac conduction system (CCS), which is …
[HTML][HTML] Молекулярные механизмы онтогенеза ритмоводителя сердца у позвоночных животных
ВС Кузьмин, АА Каменский - Вестник Московского университета …, 2021 - cyberleninka.ru
Небольшая группа миокардиальных клеток, формирующая естественный
доминирующий пейсмекер (ритмоводитель) сердца в т. н. синоатриальном узле (САУ) …
доминирующий пейсмекер (ритмоводитель) сердца в т. н. синоатриальном узле (САУ) …