Animal models of major depression and their clinical implications
Major depressive disorder is a common, complex, and potentially life-threatening mental
disorder that imposes a severe social and economic burden worldwide. Over the years …
disorder that imposes a severe social and economic burden worldwide. Over the years …
[HTML][HTML] To group or not to group? Good practice for housing male laboratory mice
Simple Summary Wild mice live in territories inhabited by one adult male, several females,
and their offspring. This cannot be replicated in the laboratory, so male mice are usually …
and their offspring. This cannot be replicated in the laboratory, so male mice are usually …
Nucleus accumbens Drd1-expressing neurons control aggression self-administration and aggression seeking in mice
We recently developed a mouse model of appetitive operant aggression and reported that
adult male outbred CD-1 mice lever-press for the opportunity to attack subordinate male …
adult male outbred CD-1 mice lever-press for the opportunity to attack subordinate male …
[HTML][HTML] Low-dose lipopolysaccharide (LPS) inhibits aggressive and augments depressive behaviours in a chronic mild stress model in mice
Background Aggression, hyperactivity, impulsivity, helplessness and anhedonia are all
signs of depressive-like disorders in humans and are often reported to be present in animal …
signs of depressive-like disorders in humans and are often reported to be present in animal …
Experience-dependent plasticity in an innate social behavior is mediated by hypothalamic LTP
S Stagkourakis, G Spigolon, G Liu… - Proceedings of the …, 2020 - National Acad Sciences
All animals can perform certain survival behaviors without prior experience, suggesting a
“hard wiring” of underlying neural circuits. Experience, however, can alter the expression of …
“hard wiring” of underlying neural circuits. Experience, however, can alter the expression of …
Understanding zebrafish aggressive behavior
KN Zabegalov, TO Kolesnikova, SL Khatsko… - Behavioural …, 2019 - Elsevier
Aggression is a common agonistic behavior affecting social life and well-being of humans
and animals. However, the underlying mechanisms of aggression remain poorly …
and animals. However, the underlying mechanisms of aggression remain poorly …
[HTML][HTML] Lateral hypothalamus orexinergic inputs to lateral habenula modulate maladaptation after social defeat stress
D Wang, A Li, K Dong, H Li, Y Guo, X Zhang, M Cai… - Neurobiology of …, 2021 - Elsevier
Social stress, a common stressor, causes multiple forms of physical and mental dysfunction.
Prolonged exposure to social stress is associated with a higher risk of psychological …
Prolonged exposure to social stress is associated with a higher risk of psychological …
Rage Against the Machine: Advancing the study of aggression ethology via machine learning.
Rationale Aggression, comorbid with neuropsychiatric disorders, exhibits with diverse
clinical presentations and places a significant burden on patients, caregivers, and society …
clinical presentations and places a significant burden on patients, caregivers, and society …
[HTML][HTML] Temporal microstructure of dyadic social behavior during relationship formation in mice
Socially competent animals must learn to modify their behavior in response to their social
partner in a contextually appropriate manner. Dominant-subordinate relationships are a …
partner in a contextually appropriate manner. Dominant-subordinate relationships are a …
[HTML][HTML] Altered Slc25 family gene expression as markers of mitochondrial dysfunction in brain regions under experimental mixed anxiety/depression-like disorder
VN Babenko, DA Smagin, AG Galyamina… - BMC neuroscience, 2018 - Springer
Background Development of anxiety-and depression-like states under chronic social defeat
stress in mice has been shown by many experimental studies. In this article, the differentially …
stress in mice has been shown by many experimental studies. In this article, the differentially …