Extensive Biotransformation Profiling of AZD8205, an Anti-B7-H4 Antibody-Drug Conjugate, Elucidates Pathways Underlying its Stability In Vivo

Y Huang, HY Tan, J Yuan, R Mu, J Yang, K Ball… - 2024 - chemrxiv.org
What happens to macromolecules in vivo? What drives structure-activity relationship and in
vivo stability for antibody-drug conjugates (ADCs)? These interrelated questions are …