The biopharmaceutical market has experienced a tremendous growth in the last years.
However, this growth should be balanced considering the difficulty in bioproduct …

A future-oriented approach is the application of Digital Twins for process development,
optimization and finally during manufacturing. Digital Twins are detailed virtual …

Abstract Model-based methods are increasingly used in all areas of biopharmaceutical
process technology. They can be applied in the field of experimental design, process …

Production of monoclonal antibodies (mAbs) is a well-known method used to synthesize a
large number of identical antibodies, which are molecules of huge importance in medicine …

Fed-batch cultures of hybridoma cells are commonly used for the production of monoclonal
antibodies (MAb). In this study, a simple macroscopic model of the cell culture is used, which …

The current paradigm for raw material control in the biopharmaceutical industry remains a
combination of compendial tests, function-based test and engineering controls. Moreover …

Multi-enzymatic reactions can successfully replace complex chemical syntheses, using
milder reaction conditions, and generating less waste. The present model-based analysis …

The maximization of biomass productivity in fed-batch cultures of hybridoma cells is
analyzed based on the overflow metabolism model. Due to overflow metabolism, often …

Hybrid kinetic models, linking structured models of cell (nano-scale) metabolic processes to
the dynamics of macroscopic variables of the bioreactor, are proven to lead to more precise …

Growth of mammalian cells in the production of biotherapeutics often require the benefits of
chemically defined media (CDM). Storage, handling and stability advantages of CDM …