Mechanisms of antimicrobial resistance in Gram-negative bacilli
É Ruppé, PL Woerther, F Barbier - Annals of intensive care, 2015 - Springer
The burden of multidrug resistance in Gram-negative bacilli (GNB) now represents a daily
issue for the management of antimicrobial therapy in intensive care unit (ICU) patients. In …
issue for the management of antimicrobial therapy in intensive care unit (ICU) patients. In …
Rationalizing antimicrobial therapy in the ICU: a narrative review
The massive consumption of antibiotics in the ICU is responsible for substantial ecological
side effects that promote the dissemination of multidrug-resistant bacteria (MDRB) in this …
side effects that promote the dissemination of multidrug-resistant bacteria (MDRB) in this …
Antimicrobial resistance in the next 30 years, humankind, bugs and drugs: a visionary approach
Purpose To describe the current standards of care and major recent advances with regard to
antimicrobial resistance (AMR) and to give a prospective overview for the next 30 years in …
antimicrobial resistance (AMR) and to give a prospective overview for the next 30 years in …
Antimicrobial de-escalation in critically ill patients: a position statement from a task force of the European Society of Intensive Care Medicine (ESICM) and European …
Background Antimicrobial de-escalation (ADE) is a strategy of antimicrobial stewardship,
aiming at preventing the emergence of antimicrobial resistance (AMR) by decreasing the …
aiming at preventing the emergence of antimicrobial resistance (AMR) by decreasing the …
A systematic review of the definitions, determinants, and clinical outcomes of antimicrobial de-escalation in the intensive care unit
Antimicrobial de-escalation (ADE) is a strategy to reduce the spectrum of antimicrobials and
aims to prevent the emergence of bacterial resistance. We present a systematic review …
aims to prevent the emergence of bacterial resistance. We present a systematic review …
[HTML][HTML] Risk factors for infections caused by carbapenem-resistant Enterobacterales: an international matched case-control-control study (EURECA)
S Pérez-Galera, JM Bravo-Ferrer, M Paniagua… - …, 2023 - thelancet.com
Background Data on risk factors for carbapenem-resistant Enterobacterales (CRE) with
wider applicability are needed to inform preventive measures and efficient design of …
wider applicability are needed to inform preventive measures and efficient design of …
Multicenter evaluation of a syndromic rapid multiplex PCR test for early adaptation of antimicrobial therapy in adult patients with pneumonia
C Monard, J Pehlivan, G Auger, S Alviset, A Tran Dinh… - Critical Care, 2020 - Springer
Background Improving timeliness of pathogen identification is crucial to allow early
adaptation of antibiotic therapy and improve prognosis in patients with pneumonia. We …
adaptation of antibiotic therapy and improve prognosis in patients with pneumonia. We …
Recent approaches for downplaying antibiotic resistance: molecular mechanisms
Antimicrobial resistance (AMR) is a ubiquitous public health menace. AMR emergence
causes complications in treating infections contributing to an upsurge in the mortality rate …
causes complications in treating infections contributing to an upsurge in the mortality rate …
Performance and impact of a multiplex PCR in ICU patients with ventilator-associated pneumonia or ventilated hospital-acquired pneumonia
N Peiffer-Smadja, L Bouadma, V Mathy, K Allouche… - Critical care, 2020 - Springer
Background Early appropriate antibiotic therapy reduces morbidity and mortality of severe
pneumonia. However, the emergence of bacterial resistance requires the earliest use of …
pneumonia. However, the emergence of bacterial resistance requires the earliest use of …
Impact of rapid multiplex PCR on management of antibiotic therapy in COVID-19-positive patients hospitalized in intensive care unit
N Maataoui, L Chemali, J Patrier, A Tran Dinh… - European Journal of …, 2021 - Springer
Because the diagnosis of co/superinfection in COVID-19 patients is challenging, empirical
antibiotic therapy is frequently initiated until microbiological analysis results. We evaluated …
antibiotic therapy is frequently initiated until microbiological analysis results. We evaluated …