Cytotoxicity of snake venom enzymatic toxins: phospholipase A2 and l-amino acid oxidase

JJ Hiu, MKK Yap - Biochemical society transactions, 2020 - portlandpress.com
The phospholipase A2 (PLA2) and l-amino acid oxidase (LAAO) are two major enzymes
found in the venoms from most snake species. These enzymes have been structurally and …

Past decade study of snake venom L-amino acid oxidase

C Guo, S Liu, Y Yao, Q Zhang, MZ Sun - Toxicon, 2012 - Elsevier
As one of the major protein (enzyme) components of snake venom (SV), l-amino acid
oxidase (LAAO) plays an important role in the toxicities and biological activities for SV …

[HTML][HTML] Snake venom L-amino acid oxidases: an overview on their antitumor effects

TR Costa, SM Burin, DL Menaldo… - Journal of Venomous …, 2014 - SciELO Brasil
The L-amino acid oxidases (LAAOs) constitute a major component of snake venoms and
have been widely studied due to their widespread presence and various effects, such as …

Snake venom toxins: Potential anticancer therapeutics

BC Offor, LA Piater - Journal of Applied Toxicology, 2024 - Wiley Online Library
Snake venom contains a cocktail of compounds dominated by proteins and peptides, which
make up the toxin. The toxin components of snake venom attack several targets in the …

[HTML][HTML] Isolation and biochemical, functional and structural characterization of a novel L-amino acid oxidase from Lachesis muta snake venom

C Bregge-Silva, MC Nonato, S de Albuquerque, PL Ho… - Toxicon, 2012 - Elsevier
The aim of this study was the isolation of the LAAO from Lachesis muta venom (LmLAAO)
and its biochemical, functional and structural characterization. Two different purification …

[HTML][HTML] Antitumor potential of the myotoxin BthTX-I from Bothrops jararacussu snake venom: evaluation of cell cycle alterations and death mechanisms induced in …

CP Silva, TR Costa, RMA Paiva, ACO Cintra… - Journal of Venomous …, 2015 - SciELO Brasil
Abstract Background Phospholipases A 2 (PLA 2 s) are abundant components of snake
venoms that have been extensively studied due to their pharmacological and …

BjussuLAAO-II, an L-amino acid oxidase from Bothrops jararacussu snake venom, impairs Toxoplasma gondii infection in human trophoblast cells and villous explants …

TA de Melo Fernandes, SC Teixeira, TR Costa… - Microbes and …, 2023 - Elsevier
One-third of the world's population is estimated to be affected by toxoplasmosis. Pregnancy-
related Toxoplasma gondii infection can cause vertical transmission, infect the fetus, and …

[HTML][HTML] CR-LAAO, an L-amino acid oxidase from Calloselasma rhodostoma venom, as a potential tool for developing novel immunotherapeutic strategies against …

TR Costa, DL Menaldo, KF Zoccal, SM Burin… - Scientific Reports, 2017 - nature.com
L-amino acid oxidases from snake venoms have been described to possess various
biological functions. In this study, we investigated the inflammatory responses induced in …

[HTML][HTML] King cobra (Ophiophagus hannah) venom L-amino acid oxidase induces apoptosis in PC-3 cells and suppresses PC-3 solid tumor growth in a tumor …

ML Lee, SY Fung, I Chung, J Pailoor… - … Journal of Medical …, 2014 - ncbi.nlm.nih.gov
King cobra (Ophiophagus hannah) venom L-amino acid oxidase (OH-LAAO), a heat stable
enzyme, has been shown to exhibit very potent anti-proliferative activity against human …

Exploration of antimicrobial and anticancer activities of L-amino acid oxidase from Egyptian Naja haje venom

WH Salama, AA Abd-Rabou, RI Bassuiny, AE El Hakim… - Toxicon, 2024 - Elsevier
Hepatocellular carcinoma and bacterial resistance are major health burdens nowadays.
Thus, providing new therapies that overcome that resistance is of great interest, particularly …