Cognitive impairment in Parkinson's disease: the dual syndrome hypothesis

AA Kehagia, RA Barker, TW Robbins - Neurodegenerative diseases, 2012 - karger.com
Research into the heterogeneous nature of cognitive impairment documented in patients
with Parkinson's disease (PD) has focused on disentangling deficits that vary between …

Mechanisms underlying motivational deficits in psychopathology: similarities and differences in depression and schizophrenia

DM Barch, D Pagliaccio, K Luking - Behavioral neuroscience of motivation, 2016 - Springer
Motivational and hedonic impairments are core aspects of a variety of types of
psychopathology. These impairments cut across diagnostic categories and may be critical to …

Pharmacological and non-pharmacological interventions to improve cognitive dysfunction and functional ability in clinical depression–a systematic review

BT Baune, L Renger - Psychiatry research, 2014 - Elsevier
Cognitive dysfunction is of clinical significance and exerts longstanding implication on
patients׳ function. Pharmacological and non-pharmacological treatments of cognitive …

Learning from negative feedback in patients with major depressive disorder is attenuated by SSRI antidepressants

MM Herzallah, AA Moustafa, JY Natsheh… - Frontiers in integrative …, 2013 - frontiersin.org
One barrier to interpreting past studies of cognition and major depressive disorder (MDD)
has been the failure in many studies to adequately dissociate the effects of MDD from the …

Exploring the cognitive and motor functions of the basal ganglia: an integrative review of computational cognitive neuroscience models

S Helie, S Chakravarthy, AA Moustafa - Frontiers in computational …, 2013 - frontiersin.org
Many computational models of the basal ganglia (BG) have been proposed over the past
twenty-five years. While computational neuroscience models have focused on closely …

D ecreased feedback learning in anorexia nervosa persists after weight restoration

K Foerde, JE Steinglass - International Journal of Eating …, 2017 - Wiley Online Library
Abstract Objective Anorexia Nervosa (AN) is a serious disorder, with a mortality rate the
highest of any psychiatric illness. It is notoriously challenging to treat and mechanisms of …

Cholinergic receptor modulation as a target for preventing dementia in Parkinson's disease

A Iarkov, C Mendoza, V Echeverria - Frontiers in Neuroscience, 2021 - frontiersin.org
Parkinson's disease (PD) is a neurodegenerative condition characterized by the loss of
dopaminergic neurons in the substantia nigra pars compacta (SNpc) in the midbrain …

Learning and generalization from reward and punishment in opioid addiction

CE Myers, J Rego, P Haber, K Morley, KD Beck… - Behavioural brain …, 2017 - Elsevier
This study adapts a widely-used acquired equivalence paradigm to investigate how opioid-
addicted individuals learn from positive and negative feedback, and how they generalize …

Neural and behavioral substrates of subtypes of Parkinson's disease

AA Moustafa, M Poletti - Frontiers in systems neuroscience, 2013 - frontiersin.org
Parkinson's disease (PD) is a neurological disorder, associated with rigidity, bradykinesia,
and resting tremor, among other motor symptoms. In addition, patients with PD also show …

Depression impairs learning, whereas the selective serotonin reuptake inhibitor, paroxetine, impairs generalization in patients with major depressive disorder

MM Herzallah, AA Moustafa, JY Natsheh… - Journal of affective …, 2013 - Elsevier
To better understand how medication status and task demands affect cognition in major
depressive disorder (MDD), we evaluated medication-naïve patients with MDD, medicated …