Radiographic axial spondyloarthritis (also known as ankylosing spondylitis [AS]) is a chronic
immune-mediated arthritis characterized by inflammation of the axial skeleton, peripheral …

Possession of the human leukocyte antigen (HLA) class I molecule B27 is strongly
associated with ankylosing spondylitis (AS), but the pathogenic role of HLA-B27 is unknown …

Introduction In this study, we analysed the number of IL-17+ cells in facet joints, in the
peripheral blood (PB) and synovial fluid (SF) of spondyloarthritis (SpA) patients and …

In our paper, we discuss how the early phases of ankylosing spondylitis (AS) are linked to
peri-firbocartilagenous osteitis in the sacroiliac joint and entheseal bone related anchoring …

The class I protein HLA-B27 confers susceptibility to inflammatory arthritis in humans and
when overexpressed in rodents for reasons that remain unclear. We demonstrated …

The mechanism by which the MHC class I allele, HLA-B27, contributes to spondyloarthritis
pathogenesis is unknown. In contrast to other alleles that have been examined, HLA-B27 …

The class I MHC allele HLA-B27 is highly associated with the human spondyloarthropathies,
but the basis for this association remains poorly understood. Transgenic rats with high …

A great deal of progress has occurred in the past few years in elucidating the causes and
designing new treatments for ankylosing spondylitis and other types of spondyloarthritis. In …

Reactive arthritis is classically seen following infection with enteric pathogens such as
Yersinia, Salmonella, Campylobacter and Shigella. Inflammatory arthritis has also been …

More than three decades after the discovery of HLA-B27 as a major genetic clue to the
origins of ankylosing spondylitis, much has been learned about pathogenesis. However, the …