Autophagy as a means of cell killing was first advanced by Clark's phenotypic description of
'Type II autophagic cell death'in 1990. However, this phenomenon later came into question …

Lipid droplets (LDs) are the organelles for storing neutral lipids, which are broken down
when energy is insufficient. It has been suggested that excessive accumulation of LDs can …

GPNMB is a glycoprotein observed upon tissue damage and inflammation and is associated
with astrocytes, microglia, and macrophages. Gene variations in GPNMB are linked with …

Cyclodextrins, representing a versatile family of cyclic oligosaccharides, have extensive
pharmaceutical applications due to their unique truncated cone-shaped structure with a …

Background: Glucocerebrosidase gene (GBA) mutations influence risk and prognosis of
Parkinson's disease (PD), possibly through accumulation of glycosphingolipids, including …

Numerous clinical observations and exploitation of cellular and animal models indicate that
glucosylceramide (GlcCer) and galactosylceramide (GalCer) are involved in many …

Simple Summary Receptor tyrosine kinases probably constitute the most important
subfamily of transmembrane receptors with respect to their role in regulating the balance …

Ceramides (Cer) constitute a class of lipids present in the cell membranes where they act as
structural components, but they can also work as signaling molecules. Increasing genetic …

β-glucocerebrosidase is a lysosomal hydrolase involved in the catabolism of the
sphingolipid glucosylceramide. Biallelic loss of function mutations in this enzyme are …

Sphingolipids represent a class of bioactive lipids that modulate the biophysical properties
of biological membranes and play a critical role in cell signal transduction. Multiple studies …