Peptide and protein (P/P) drugs have been identified as showing great promises for the
treatment of various neurodegenerative diseases. A major challenge in this regard …

Alzheimer's disease is widely held to be associated with oxidative stress due, in part, to the
membrane action of β‐amyloid peptide aggregates. Here, we studied the effect of …

Using the Braak staging for neurofibrillary changes as an objective indicator of the
progression of Alzheimer's disease, we have performed a systematic search for global gene …

Pituitary adenylate cyclase activating polypeptide (PACAP) is a pleiotropic and
multifunctional peptide exerting its effects via 3 main receptors (PAC1, VPAC1 and VPAC2) …

Pituitary adenylate cyclase-activating polypeptide (PACAP) has been reported to decrease
ischemic neuronal damage and increase IL-6 secretion in rats. However, the mechanisms …

Pituitary adenylate cyclase activating polypeptide (PACAP) was first isolated from
hypothalamic extracts on the basis of its ability to stimulate cAMP formation in pituitary cells …

Alzheimer's disease (AD) is an age-related neurodegenerative disorder characterized by
cognitive deficits and neuronal loss. Deposition of beta-amyloid peptide (Aβ) causes …

Pituitary adenylate cyclase activating polypeptide (PACAP), vasoactive intestinal peptide
(VIP) and peptide histidine-isoleucine (PHI), are structurally related endogenous peptides …

PACAP/VIP as well as their three classes of receptors are important in many physiological/
pathophysiological processes, some of which are identified in these studies using knockout …

Pituitary adenylate cyclase activating polypeptide (PACAP) is a neurotrophin. However, its
role in human Alzheimer's disease (AD) is largely unknown. We examined PACAP …