Disorders of cell number that result from an imbalance between the death of parenchymal
cells and the proliferation or recruitment of maladaptive cells contributes to the pathogenesis …

Chronic kidney disease (CKD) is a devastating condition that is reaching epidemic levels
owing to the increasing prevalence of diabetes mellitus, hypertension and obesity, as well …

Mitochondria are essential for the activity, function and viability of eukaryotic cells and
mitochondrial dysfunction is involved in the pathogenesis of acute kidney injury (AKI) and …

Acute kidney injury (AKI) is morphologically characterized by a synchronized plasma
membrane rupture of cells in a specific section of a nephron, referred to as acute tubular …

Ferroptosis is a recently recognized cell death modality that is morphologically,
biochemically and genetically distinct from other forms of cell death and that has emerged to …

Various forms of cell death have been identified over the last decades with each relying on a
different subset of proteins for the activation and execution of their respective pathway (s). In …

Nonapoptotic forms of cell death can trigger sterile inflammation through the release of
damage-associated molecular patterns, which are recognized by innate immune receptors …

Necroptosis is a genetically regulated form of necrotic cell death that has emerged as an
important pathway in human disease. The necroptosis pathway is induced by a variety of …

Abstract Necrostatin-1 (Nec-1) is a RIP1-targeted inhibitor of necroptosis, a form of
programmed cell death discovered and investigated in recent years. There are already …

Ferroptosis is a non-apoptotic form of cell death characterized by overwhelming iron-
dependent lipid peroxidation, which contributes to a number of pathologies, most notably …