Amino acids are necessary for all living cells and organisms. Specialized transporters
mediate the transfer of amino acids across plasma membranes. Malfunction of these …

Chronic proliferation is a major hallmark of tumor cells. Rapidly proliferating cancer cells are
highly dependent on nutrients in order to duplicate their cell mass during each cell division …

Cellular oxidative and electrophilic stress triggers a protective response in mammals
regulated by NRF2 (nuclear factor (erythroid-derived) 2-like; NFE2L2) binding to …

Integrins are heterodimeric cell surface receptors that bind to different extracellular ligands
depending on their composition and regulate all processes which enable multicellular life. In …

Adaptive immunity, a vertebrate specialization, adds memory and exquisite specificity to the
basic innate immune responses present in invertebrates while conserving metabolic …

Background: The expression of L-type amino-acid transporter 1 (LAT1) is tumour-specific
and has been shown to have essential roles in cell growth and survival. However, little is …

Simple Summary ASCT2 and LAT1 are amino acid transporters whose impact in cancer has
been explored throughout the years. They have been associated with most currently …

Colon cancer is among the most widely occurring cancer types, leading to considerably high
mortality rate. The current chemotherapy achieves only limited success, and more effective …

Despite intensive efforts to improve therapies, small cell lung cancer (SCLC) still has a
dismal median survival of 18 months. Since miR-126 is under-expressed in the majority of …

The SLC3A2 gene encodes for a cell-surface transmembrane protein CD98hc (4F2).
CD98hc serves as a chaperone for LAT1 (SLC7A5), LAT2 (SLC7A8), y+ LAT1 (SLC7A7), y+ …