Integrins are the major family of adhesion molecules that mediate cell adhesion to the
extracellular matrix. They are essential for embryonic development and influence numerous …

The extracellular matrix (ECM) is a highly dynamic system that constantly offers physical,
biological, and chemical signals to embraced cells. Increasing evidence suggests that …

The cytoskeleton of animal cells is one of the most complicated and functionally versatile
structures, involved in processes such as endocytosis, cell division, intra-cellular transport …

Dynamic regulation of the filamentous actin (F-actin) cytoskeleton is critical to numerous
physical cellular processes, including cell adhesion, migration and division. Each of these …

The molecular requirements and morphology of migrating cells can vary depending on
matrix geometry; therefore, predicting the optimal migration strategy or the effect of …

Some of the key steps in cancer metastasis are the migration and invasion of tumor cells;
these processes require rearrangement of the cytoskeleton. Actin filaments, microtubules …

Neurite outgrowth underlies the wiring of the nervous system during development and
regeneration. Despite a significant body of research, the underlying cytoskeletal mechanics …

Although many details remain still elusive, it became increasingly evident in recent years
that mechanosensing of microenvironmental biophysical cues and subsequent …

Adherens junctions (AJs) are mechanosensitive cadherin-based intercellular adhesions that
interact with the actin cytoskeleton and carry most of the mechanical load at cell–cell …

The brain is our most complex organ. During development, neurons extend axons, which
may grow over long distances along well-defined pathways to connect to distant targets. Our …