Interferon (IFN)-mediated antiviral responses are central to host defence against viral
infection. Despite the existence of at least 20 IFNs, there are only three known cell surface …

The co-evolution of viruses with their hosts has led to the emergence of viral pathogens that
are adept at evading or actively suppressing host immunity. Pattern recognition receptors …

A characteristic feature of COVID‐19, the disease caused by severe acute respiratory
syndrome coronavirus 2 (SARS‐CoV‐2) infection, is the dysregulated immune response …

Double-stranded DNA (dsDNA) sensor cyclic-GMP-AMP synthase (cGAS) along with the
downstream stimulator of interferon genes (STING) acting as essential immune-surveillance …

Upon virus infection, host cells mount a concerted innate immune response involving type I
interferon and pro-inflammatory cytokines to enable elimination of the pathogen. Recently …

The first line of host defense against infectious agents involves activation of innate immune
signaling pathways that recognize specific pathogen-associated molecular patterns …

Background & Aims XBP1 modulates the macrophage proinflammatory response, but its
function in macrophage stimulator of interferon genes (STING) activation and liver fibrosis is …

The past decade has provided critical information about the cytoplasmic innate immune
sensing pathway of cyclic GMP-AMP synthase (cGAS) and stimulator of interferon genes …

The limited host tropism of numerous viruses causing disease in humans remains
incompletely understood. One example is Zika virus (ZIKV), an RNA virus that has …

In mammalian cells, IFN responses that occur during RNA and DNA virus infections are
activated by distinct signaling pathways. The RIG-I–like-receptors (RLRs) bind viral RNA …