DNA methylation patterns are disrupted in various malignancies, suggesting a role in the
development of cancer, but genetic aberrations directly linking the DNA methylation …

It is becoming clear that epigenetic changes are involved in human disease as well as
during normal development. A unifying theme of disease epigenetics is defects in …

This paper provides a review of the design and analysis of genetic association studies. In
case control studies, the different contingency tables and their relationships to the …

We report here genome-wide mapping of DNA methylation patterns at proximal promoter
regions in mouse embryonic stem (mES) cells. Most methylated genes are differentiation …

Understanding the molecular mechanism by which pluripotency is maintained in human
embryonic stem cells (hESC) is important for the development of improved methods to …

The mammalian intestinal epithelium has a unique organization in which crypts harboring
stem cells produce progenitors and finally clonal populations of differentiated cells …

Early studies proposed that DNA methylation could have a role in regulating gene
expression during development [Riggs, AD (1975) Cytogenet. Cell Genet. 14, 9–25] …

Dimethyl sulfoxide (DMSO), an amphipathic molecule, is widely used not only as a solvent
for water‐insoluble substances but also as a cryopreservant for various types of cells …

The promise of human embryonic stem cell (hESC) lines for treating injuries and
degenerative diseases, for understanding early human development, for disease modelling …

The process of DNA CpG methylation has been extensively investigated for over 50 years
and revealed associations between changing methylation status of CpG islands and gene …