Tumor cells escape the immune surveillance system of the host through a process called
immune tolerance. Immunotherapy targets molecules that serve as checks and balances in …

Glioma is one of the most common malignant tumors of the central nervous system and is
characterized by extensive infiltrative growth, neovascularization, and resistance to various …

Currently, gliomas are diagnosed by neuroimaging, and refined diagnosis requires
resection or biopsy to obtain tumour tissue for histopathological classification and grading …

The central nervous system (CNS) possesses powerful local and global immunosuppressive
capabilities that modulate unwanted inflammatory reactions in nervous tissue. These same …

Survivin is an anti-apoptotic protein that is highly expressed in many cancers, including
malignant gliomas. Preclinical studies established that the conjugated survivin peptide …

Glioblastoma is the most common primary brain tumor in adults and still remains incurable,
due to the limited accumulation of drugs in the tumor area. Herein, iRGD‐modified …

Glioblastoma (GBM) is the most common and fatal primary malignant brain tumor. Despite
advances in the understanding of the biology of gliomas, little has changed in the treatment …

Treg cells are key elements of the immune system which are responsible for the immune
suppressive phenotype of cancer patients. Interaction of Treg cells with conventional …

Abstract Background: Fibrinogen-like protein 2 (FGL2) may promote glioblastoma multiforme
(GBM) cancer development by inducing multiple immune-suppression mechanisms …

OBJECT Circulating microRNAs (miRNAs) are a new class of highly promising cancer
biomarkers. Malignant glioma is one of the most devastating and lethal forms of intrinsic …