Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) has rapidly spread in
humans in almost every country, causing the disease COVID-19. Since the start of the …

Blocking the biological functions of scaffold proteins and aggregated proteins is a
challenging goal. PROTAC proteolysis-targeting chimaera (PROTAC) technology may be …

The N‐end rule relates the regulation of the in vivo half‐life of a protein to the identity of its N‐
terminal residue. Degradation signals (degrons) that are targeted by the N‐end rule pathway …

Toll-like receptors (TLRs) sense invading microbial pathogens and play crucial roles in the
activation of innate and adaptive immunity. However, excessive TLR activation can disrupt …

The ubiquitin proteasome system (UPS) and macroautophagy (hereafter called autophagy)
were, for a long time, regarded as independent degradative pathways with few or no points …

Organisms are constantly exposed to microbial pathogens in their environments. When a
pathogen meets its host, a series of intricate intracellular interactions shape the outcome of …

The evolutionarily conserved cullin family proteins can assemble as many as 400 distinct E3
ubiquitin ligase complexes that regulate diverse cellular pathways. CUL4, one of three …

Although cellular proteins conjugated to K48‐linked Ub chains are targeted to proteasomes,
proteins conjugated to K63‐ubiquitin chains are directed to lysosomes. However, pure 26S …

Animal diseases constitute a continuing threat to animal health, food safety, national
economy, and the environment. Among those, African swine fever (ASF) is one of the most …

In the last decade, the ubiquitin–proteasome system has emerged as a valid target for the
development of novel therapeutics. E3 ubiquitin ligases are particularly attractive targets …