In many cases, the mechanical properties of a tumor are different from those of the host
tissue. Mechanical cues regulate cancer development by affecting both tumor cells and their …

Simple Summary Connexins are proteins which comprise gap junctions in cells. These
junctions can directly connect neighboring cells and the cell interior with the extracellular …

Although natural killer (NK) cells play an important role in the control of melanoma, hypoxic
stress in the tumor microenvironment may impair NK-mediated tumor cell killing by …

Background and Aims Connexins and their cell membrane channels contribute to the control
of cell proliferation and compartmental functions in breast glands and their deregulation is …

Connexins (Cxs) are a family of proteins that form two different types of ion channels:
hemichannels and gap junction channels. These channels participate in cellular …

Gap junctions (GJs), essential structures for cell-cell communication, are made of two
hemichannels (commonly called connexons), one on each adjacent cell. Found in almost all …

The commencement of cancer is attributed to one or a few cells that become rogue and
attain the property of immortality. The inception of distinct cancer cell clones during the …

Under normal conditions, almost all cell types communicate with their neighboring cells
through gap junction channels (GJC), facilitating cellular and tissue homeostasis. A GJC is …

Alterations in microRNA (miRNA) profiles, induced by tumor microenvironment stressors,
like hypoxia, allow cancer cells to acquire immune-resistance phenotypes. Indeed, hypoxia …

Gap junctions are cell‐to‐cell junctions that are located in the basolateral surface of two
adjoining cells. A gap junction channel is composed of a family of proteins called connexins …