Ultrahigh dose-rate radiotherapy (RT), or'FLASH'therapy, has gained significant momentum
following various in vivo studies published since 2014 which have demonstrated a reduction …

The blood–brain barrier (BBB) is formed by brain microvascular endothelial cells that are
sealed by tight junctions, making it a significant obstacle for most brain therapeutics. The …

This study is the first proof of concept that the FLASH effect can be triggered by X-rays. Our
results show that a 10 Gy whole-brain irradiation delivered at ultra-high dose-rate with …

It is well known that the density of neurons varies within the adult brain. In neocortex, this
includes variations in neuronal density between different lamina as well as between different …

Aim Viviparity has evolved more times in squamates than in any other vertebrate group;
therefore, squamates offer an excellent model system in which to study the patterns, drivers …

The visualization of cerebral microvessels is essential for understanding brain remodeling
after stroke. Injection of dyes allows for the evaluation of perfused vessels, but has …

Microbeam radiation therapy (MRT) uses highly collimated, quasi-parallel arrays of X-ray
microbeams of 50–600keV, produced by third generation synchrotron sources, such as the …

PURPOSE: Synchrotron microbeam radiation therapy (MRT) relies on spatial fractionation of
the incident photon beam into parallel micron-wide beams. Our aim was to analyze the …

Studies have shown that x-rays delivered as arrays of parallel microplanar beams
(microbeams), 25-to 90-μm thick and spaced 100–300 μm on-center, respectively, spare …

Astrocytes connect the vasculature to neurons mediating the supply of nutrients and
biochemicals. They are involved in a growing number of physiological and …