Tracking cancer evolution through the disease course
During cancer evolution, constituent tumor cells compete under dynamic selection
pressures. Phenotypic variation can be observed as intratumor heterogeneity, which is …
pressures. Phenotypic variation can be observed as intratumor heterogeneity, which is …
Lung cancer epigenetics: from knowledge to applications
M Duruisseaux, M Esteller - Seminars in cancer biology, 2018 - Elsevier
Lung cancer is the leading cause of cancer-related mortality worldwide. Advances in our
understanding of the genomics of lung cancer have led to substantial progress in the …
understanding of the genomics of lung cancer have led to substantial progress in the …
The protein expression profile of ACE2 in human tissues
The novel SARS‐coronavirus 2 (SARS‐CoV‐2) poses a global challenge on healthcare and
society. For understanding the susceptibility for SARS‐CoV‐2 infection, the cell type‐specific …
society. For understanding the susceptibility for SARS‐CoV‐2 infection, the cell type‐specific …
Phenotype molding of stromal cells in the lung tumor microenvironment
Cancer cells are embedded in the tumor microenvironment (TME), a complex ecosystem of
stromal cells. Here, we present a 52,698-cell catalog of the TME transcriptome in human …
stromal cells. Here, we present a 52,698-cell catalog of the TME transcriptome in human …
A pathology atlas of the human cancer transcriptome
INTRODUCTION Cancer is a leading cause of death worldwide, and there is great need to
define the molecular mechanisms driving the development and progression of individual …
define the molecular mechanisms driving the development and progression of individual …
Molecular signature of subtypes of non-small-cell lung cancer by large-scale transcriptional profiling: identification of key modules and genes by weighted gene co …
M Niemira, F Collin, A Szalkowska, A Bielska… - Cancers, 2019 - mdpi.com
Non-small-cell lung cancer (NSCLC) represents a heterogeneous group of malignancies
consisting essentially of adenocarcinoma (ADC) and squamous cell carcinoma (SCC) …
consisting essentially of adenocarcinoma (ADC) and squamous cell carcinoma (SCC) …
Workflow enabling deepscale immunopeptidome, proteome, ubiquitylome, phosphoproteome, and acetylome analyses of sample-limited tissues
Serial multi-omic analysis of proteome, phosphoproteome, and acetylome provides insights
into changes in protein expression, cell signaling, cross-talk and epigenetic pathways …
into changes in protein expression, cell signaling, cross-talk and epigenetic pathways …
[HTML][HTML] PD-L1 immunohistochemistry in clinical diagnostics of lung cancer: inter-pathologist variability is higher than assay variability
H Brunnström, A Johansson, S Westbom-Fremer… - Modern Pathology, 2017 - Elsevier
Assessment of programmed cell death ligand 1 (PD-L1) immunohistochemical staining is
used for decision on treatment with programmed cell death 1 and PD-L1 checkpoint …
used for decision on treatment with programmed cell death 1 and PD-L1 checkpoint …
Multispectral imaging for quantitative and compartment‐specific immune infiltrates reveals distinct immune profiles that classify lung cancer patients
A Mezheyeuski, CH Bergsland… - The Journal of …, 2018 - Wiley Online Library
Semiquantitative assessment of immune markers by immunohistochemistry (IHC) has
significant limitations for describing the diversity of the immune response in cancer …
significant limitations for describing the diversity of the immune response in cancer …
CD44 promotes PD-L1 expression and its tumor-intrinsic function in breast and lung cancers
Abstract The PD-L1 (CD274) immune-checkpoint ligand is often upregulated in cancers to
inhibit T cells and elicit immunosuppression. Independent of this activity, PD-L1 has recently …
inhibit T cells and elicit immunosuppression. Independent of this activity, PD-L1 has recently …